Department of Pediatrics, Benha Faculty of Medicine, Benha University, Benha, Egypt.
Department of Clinical Pathology and Chemistry, Benha Faculty of Medicine, Benha University, Benha, Egypt.
Am J Perinatol. 2024 Jan;41(2):143-149. doi: 10.1055/s-0041-1740074. Epub 2021 Nov 28.
The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS).
One-hundred twenty term neonates along with their mothers were enrolled in this case-control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts.
Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL, respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively) = 0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay ( = -0.616 and -0.596, respectively) <0.001 for both. With a cut-off value of 12.9 ng/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI = 1.034-1.144)) for LOS in vitamin D-deficient neonates.
Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS.
· Neonatal and maternal vitamin D deficiency increase risk of LOS.. · Neonatal vitamin D correlates with maternal vitamin D.. · Neonatal vitamin D is independent predictor for LOS..
本研究旨在探讨新生儿和产妇维生素 D 与晚发性败血症（LOS）的关系。
本病例对照研究纳入了 120 例足月新生儿及其母亲。60 例因 LOS 入住新生儿重症监护病房且在过去 48 小时内未入院、未接受抗生素或维生素 D 治疗的新生儿被纳入病例（败血症）组。另一方面，60 例健康足月新生儿被作为对照组。对两组新生儿和产妇的血清 25-羟维生素 D 水平进行评估。
病例组（分别为 17.2 和 16.1ng/mL）的产妇和新生儿 25-羟维生素 D 水平明显低于对照组（分别为 22.7 和 21ng/mL），差异具有统计学意义（P=0.001）。在研究组中，新生儿 25-羟维生素 D 与 C 反应蛋白和住院时间呈负相关（分别为 r=-0.616 和 -0.596，P<0.001）。当新生儿 25-羟维生素 D 水平的截断值为 12.9ng/mL 时，其对 LOS 的特异性和阳性预测值分别为 83.3%和 74.4%。维生素 D 缺乏的新生儿发生 LOS 的比值比为 1.088（95%CI=1.034-1.144）。
维生素 D 水平较高的新生儿发生 LOS 的风险低于维生素 D 缺乏的新生儿。产妇维生素 D 与新生儿维生素 D 相关。这些数据表明，孕妇补充维生素 D 可能降低 LOS 的风险。
· 新生儿和产妇维生素 D 缺乏会增加 LOS 的风险。
· 新生儿维生素 D 与产妇维生素 D 相关。
· 新生儿维生素 D 是 LOS 的独立预测因素。
