Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.
Department of genetics, Akbarabadi Hospital, Iran University of Medical Sciences, Tehran, Iran.
Lipids Health Dis. 2019 Jul 13;18(1):153. doi: 10.1186/s12944-019-1095-3.
The goal of this study was to evaluate the relationship between maternal 25-OH Vitamin D serum levels and neonatal early-onset sepsis in newborns by the effective factors.
A case-control study was done and 64 neonates hospitalized in Akbar Abadi Hospital (Tehran- Iran; 2016) and their mothers were enrolled. The case group consisted of 32 NICU term hospitalized neonates due to neonatal early-onset sepsis. Thirty-two term newborns that referred to hospital for rule out hyperbilirubinemia during the first 72 h of life were also considered as the control.
Sixty- four mothers with mean age 28.76 ± 6.60 years and mean gestational age 39.64 ± 1.62 weeks entered the study. There was a significant correlation between sepsis and older age of mothers and low Apgar score (P-value = 0.02, 0.01 respectively). The maternal vitamin D serum level was reversely correlated with neonatal sepsis occurrence (P-value = 0.03). There was a significant correlation between maternal vitamin D supplement intake during pregnancy and lower risk for neonatal sepsis (P-value = 0.003).
The level of maternal serum Vitamin D was inversely correlated with neonatal sepsis occurrence and intake of vitamin D supplement during pregnancy could decrease the risk of early neonatal sepsis.
本研究旨在评估母体 25-羟维生素 D 血清水平与新生儿早发性败血症之间的关系，并考虑到有效因素。
进行了一项病例对照研究，纳入了 2016 年在阿巴丹阿克巴尔医院（德黑兰，伊朗）住院的 64 名新生儿及其母亲。病例组包括 32 名因新生儿早发性败血症而住院的 NICU 足月新生儿。还将 32 名在出生后 72 小时内因高胆红素血症而住院的足月新生儿作为对照组。
64 名母亲的平均年龄为 28.76±6.60 岁，平均孕龄为 39.64±1.62 周。败血症与母亲年龄较大和低阿普加评分呈显著相关（P 值分别为 0.02 和 0.01）。母亲维生素 D 血清水平与新生儿败血症的发生呈负相关（P 值为 0.03）。母亲在怀孕期间补充维生素 D 与新生儿败血症的风险降低呈显著相关（P 值为 0.003）。
母体血清维生素 D 水平与新生儿败血症的发生呈负相关，怀孕期间补充维生素 D 可降低新生儿早发性败血症的风险。
