维生素 D 缺乏在足月新生儿晚发性败血症中的作用：病例对照研究。

Role of Vitamin-D Deficiency in Term Neonates with Late-Onset Sepsis: A Case-Control Study.

机构信息

Department of Pediatrics, Gandhi Medical College, Hamidia Hospital, Bhopal, Madhya Pradesh, India.

出版信息

J Trop Pediatr. 2019 Dec 1;65(6):609-616. doi: 10.1093/tropej/fmz021.

DOI:10.1093/tropej/fmz021

PMID:31006010

Abstract

OBJECTIVE

To find the relationship between vitamin-D levels and late-onset sepsis (LOS) in term neonates.

METHODS

This case-control study was conducted in neonatal intensive care unit of a tertiary care teaching institution in central India. Full-term neonates with culture-proven LOS were taken as cases. Maternal and neonatal demography, clinical examination and investigations were recorded. Correlation of vitamin-D deficiency (<20 ng/ml) with LOS was assessed.

RESULTS

Total 225 term neonates including 175 cases and 50 controls were included. Maternal and neonatal demographic profile was comparable. The mean vitamin-D level in cases (12.28 ± 6.11 ng/ml) was significantly lower than that in controls (14.88 ± 7.2 ng/ml) (p = 0.002). Total 151 (86.29%) neonates out of 175 cases and 37 (74%) out of 50 controls had the vitamin-D deficiency (p = 0.00003). On multiple regression analysis, neonatal sepsis (p = 0.00003) was found to be significantly associated with vitamin-D deficiency.

CONCLUSION

This study shows that vitamin-D deficiency in term neonates may predispose them to LOS.

摘要

目的

探讨足月新生儿维生素 D 水平与晚发型败血症（LOS）的关系。

方法

这是一项在印度中部一家三级教学医院新生儿重症监护病房进行的病例对照研究。将培养证实 LOS 的足月新生儿作为病例。记录产妇和新生儿的人口统计学、临床检查和调查结果。评估维生素 D 缺乏（<20ng/ml）与 LOS 的相关性。

结果

共纳入 225 例足月新生儿，包括 175 例病例和 50 例对照。母体和新生儿的人口统计学特征相似。病例组的平均维生素 D 水平（12.28±6.11ng/ml）明显低于对照组（14.88±7.2ng/ml）（p=0.002）。175 例病例中有 151 例（86.29%）和 50 例对照中有 37 例（74%）存在维生素 D 缺乏（p=0.00003）。多元回归分析显示，新生儿败血症（p=0.00003）与维生素 D 缺乏显著相关。