Departments of Otolaryngology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Head Neck. 2022 Feb;44(2):443-452. doi: 10.1002/hed.26944. Epub 2021 Nov 29.
BACKGROUND: The authors aimed to define novel gene expression signatures that are associated with patients' survival with head and neck squamous cell carcinoma (HNSCC). METHODS: TCGA RNA-seq data were used for gene expression clusters extraction from 499 tumor samples by the "EPIG" method. Tumor samples were then partitioned into lower and higher than median level groups for survival relevant analysis by Kaplan-Meier estimator. RESULTS: We found that two gene clusters (_1, _2) are favorably, while two (_3, _4) are unfavorably, associated with patients' survival with HNSCC. Notably, most genes on the top lists of cluster_2 are associated with B cells. A gene expression signature with combined genes from cluster_2 and _4 was further determined to be associated with HNSCC survival rate. CONCLUSION: Our work strongly supported a favorable role of B cells in patients' survival with HNSCC and identified a novel coexpressed gene signature as prognostic biomarker for patients' survival with HNSCC estimation.
背景：作者旨在定义与头颈部鳞状细胞癌（HNSCC）患者生存相关的新型基因表达特征。
方法：使用 TCGA RNA-seq 数据，通过“EPIG”方法从 499 个肿瘤样本中提取基因表达簇。然后通过 Kaplan-Meier 估计器将肿瘤样本分为低于和高于中位数水平的组进行生存相关分析。
结果：我们发现两个基因簇（_1、_2）与 HNSCC 患者的生存有利相关，而两个基因簇（_3、_4）与 HNSCC 患者的生存不利相关。值得注意的是，簇_2 中大多数基因与 B 细胞有关。进一步确定了来自簇_2 和 _4 的组合基因的基因表达特征与 HNSCC 生存率相关。
结论：我们的工作强烈支持 B 细胞在 HNSCC 患者生存中的有利作用，并确定了一种新的共表达基因特征作为 HNSCC 患者生存估计的预后生物标志物。
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