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通过丘脑中央中核毁损术治疗幻肢痛

Management of Phantom Limb Pain through Thalamotomy of the Centro-Median Nucleus.

作者信息

Pérez de la Torre Ramiro A, Rodríguez Hernández Job J, Al-Ramadan Ali, Gharaibeh Abeer

机构信息

Department of Research, Insight Institute of Neuroscience and Neurosurgery, 4800 Saginaw St., Flint, MI 48507, USA.

Insight Research Institute, 4800 Saginaw St., Flint, MI 48507, USA.

出版信息

Neurol Int. 2021 Nov 10;13(4):587-593. doi: 10.3390/neurolint13040058.

Abstract

Phantom limb syndrome is defined as the perception of intense pain or other sensations that are secondary to a neural lesion in a limb that does not exist. It can be treated using pharmacological and surgical interventions. Most medications are prescribed to improve patients' lives; however, the response rate is low. In this case report, we present a case of phantom limb syndrome in a 42-year-old female with a history of transradial amputation of the left thoracic limb due to an accidental compression one year before. The patient underwent placement of a deep brain stimulator at the ventral posteromedial nucleus (VPM) on the right side and removal secondary to loss of battery. The patient continued to have a burning pain throughout the limb with a sensation of still having the limb, which was subsequently diagnosed as phantom limb syndrome. After a thorough discussion with the patient, a right stereotactic centro-median thalamotomy was offered. An immediate response was reported with a reduction in pain severity on the visual analogue scale (VAS) from a value of 9-10 preoperative to a value of 2 postoperative, with no postoperative complications. Although phantom limb pain is one of the most difficult to treat conditions, centro-median thalamotomy may provide an effective stereotactic treatment procedure with adequate outcomes.

摘要

幻肢综合征被定义为在不存在的肢体中继发于神经损伤的强烈疼痛或其他感觉的感知。它可以通过药物和手术干预进行治疗。大多数药物的开具是为了改善患者的生活;然而,有效率较低。在本病例报告中,我们呈现了一名42岁女性的幻肢综合征病例,该患者一年前因意外压迫导致左胸肢经桡骨截肢。患者接受了右侧腹后内侧核(VPM)深部脑刺激器植入,后因电池耗尽而取出。患者整个肢体持续存在灼痛,并伴有仍有该肢体的感觉,随后被诊断为幻肢综合征。在与患者进行充分讨论后,为其实施了右侧立体定向中央中脑切开术。据报告,术后立即见效,视觉模拟评分(VAS)疼痛严重程度从术前的9 - 10降至术后的2,且无术后并发症。尽管幻肢痛是最难治疗的病症之一,但中央中脑切开术可能提供一种有效的立体定向治疗方法,并产生足够的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7baf/8628935/2f70d32b945c/neurolint-13-00058-g001.jpg

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