Lee Jong-Kyun, Jee Yong-Seok
Department of Exercise Immunity for Cancers, Seoul Songdo Hospital, Seoul, Korea.
Research Institute of Sports and Industry Science, Hanseo University, Seosan, Korea.
Int Neurourol J. 2021 Nov;25(Suppl 2):S96-105. doi: 10.5213/inj.2142346.173. Epub 2021 Nov 30.
The purpose of this study was to elucidate the effect of resistance exercise on skeletal muscle mass-related fitness and acquired immune cell function in ovarian cancer survivors.
Twelve ovarian cancer survivors aged 33-61 years participated voluntarily in this study and were divided into control group (CG, n=6) and exercise group (EG, n=6). They underwent removal of ovarian cancer and received regular care for over one year. Resistance exercise was used as the intervention program conducted 4 days a week for 12 weeks. Skeletal muscle mass, muscle strength, and endurance were assessed at baseline and at week 12. Other dependent variables included adaptive immunocytes related to helper T (Th) cells and immunosuppressors (CD4+ and CD8+).
After the intervention, skeletal muscle mass showed positive changes in EG com-pared to CG, although not significantly different. Muscle strength and endurance significantly increased in EG, while there was no significant change in CG. Th1, Th2, and Th1/Th2 ratio were significantly different between both groups. CD4+CD25+T cells and CD4+PD-1+T cells of EG were lower than those of CG. CD8+PD-1+T cells and CD8+TIGIT+T of EG were lower than those of CG. These results can be interpreted as the improved sensitivity of CD4+ and CD8+, which helps the secretion of myokines and cytokines, when cytotoxic substances are injected into the human body.
This study suggests that resistance training improves upon desirable changes in adaptive immune cell responses in ovarian cancer survivors by maintaining skeletal muscle mass while developing strength and endurance.
本研究旨在阐明抗阻运动对卵巢癌幸存者骨骼肌质量相关健康状况及获得性免疫细胞功能的影响。
12名年龄在33 - 61岁的卵巢癌幸存者自愿参与本研究，分为对照组（CG，n = 6）和运动组（EG，n = 6）。她们均接受了卵巢癌切除手术，并接受了一年多的常规护理。抗阻运动作为干预方案，每周进行4天，共12周。在基线和第12周时评估骨骼肌质量、肌肉力量和耐力。其他因变量包括与辅助性T（Th）细胞和免疫抑制剂相关的适应性免疫细胞（CD4 + 和CD8 +）。
干预后，与CG组相比，EG组骨骼肌质量呈正向变化，尽管差异不显著。EG组肌肉力量和耐力显著增加，而CG组无显著变化。两组间Th1、Th2及Th1/Th2比值存在显著差异。EG组的CD4 + CD25 + T细胞和CD4 + PD - 1 + T细胞低于CG组。EG组的CD8 + PD - 1 + T细胞和CD8 + TIGIT + T低于CG组。这些结果可以解释为，当向人体注射细胞毒性物质时，CD4 + 和CD8 + 的敏感性提高，这有助于肌动蛋白和细胞因子的分泌。
本研究表明，抗阻训练通过维持骨骼肌质量，同时增强力量和耐力，改善了卵巢癌幸存者适应性免疫细胞反应的理想变化。
