Electrical and Electronic Engineering, National University of Ireland Galway, Ireland; Translational Medical Device Lab, National University of Ireland Galway, Ireland.
Department of Electronic Engineering, BioMIT, Universitat Politècnica de València, Valencia, Spain.
Comput Methods Programs Biomed. 2022 Feb;214:106546. doi: 10.1016/j.cmpb.2021.106546. Epub 2021 Nov 18.
This review begins with a rationale of the importance of theoretical, mathematical and computational models for radiofrequency (RF) catheter ablation (RFCA). We then describe the historical context in which each model was developed, its contribution to the knowledge of the physics of RFCA and its implications for clinical practice. Next, we review the computer modeling studies intended to improve our knowledge of the biophysics of RFCA and those intended to explore new technologies. We describe the most important technical details of the implementation of mathematical models, including governing equations, tissue properties, boundary conditions, etc. We discuss the utility of lumped element models, which despite their simplicity are widely used by clinical researchers to provide a physical explanation of how RF power is absorbed in different tissues. Computer model verification and validation are also discussed in the context of RFCA. The article ends with a section on the current limitations, i.e. aspects not yet included in state-of-the-art RFCA computer modeling and on future work aimed at covering the current gaps.
本综述首先阐述了理论、数学和计算模型对于射频（RF）导管消融（RFCA）的重要性。然后，我们描述了每个模型开发的历史背景、对 RFCA 物理知识的贡献及其对临床实践的影响。接下来，我们回顾了旨在提高我们对 RFCA 生物物理学认识的计算机建模研究，以及旨在探索新技术的计算机建模研究。我们描述了实施数学模型的最重要技术细节，包括控制方程、组织特性、边界条件等。我们讨论了集总元件模型的实用性，尽管它们很简单，但临床研究人员广泛使用这些模型来提供对 RF 功率如何在不同组织中被吸收的物理解释。本文还讨论了 RFCA 背景下的计算机模型验证和确认。文章最后一节讨论了当前的局限性，即尚未包含在最先进的 RFCA 计算机建模中的方面，以及旨在弥补当前差距的未来工作。
