Faculty of Pharmacy, Department of Biochemistry, Agri Ibrahim Cecen University, 04100, Agri, Turkey.
Faculty of Pharmacy, Department of Biochemistry, Ataturk University, 25240, Erzurum, Turkey.
Appl Biochem Biotechnol. 2022 Apr;194(4):1645-1658. doi: 10.1007/s12010-021-03753-z. Epub 2021 Nov 30.
Streptozotocin (STZ) is an antitumor antibiotic indicating in the treatment of metastatic islet cell carcinoma of the pancreas. It is also used as a tool to create experimental diabetes models. The STZ exposure at a high dose causes severe damage to cells of humans and other mammals. The goal of the present study was to assess the protective effects of the ethanol extract of the Myrtle (Myrtus communis L.) berries, which is a well-known medicinal plant due to its rich phenolic content and beneficial effects on health, against STZ-induced oxidative stress in the diabetic rats.Diabetes was induced by STZ (40 mg/kg, i.p.) in the rats. After diabetes induction, a significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), and blood glucose levels as well as a significant decrease in superoxide dismutase (SOD) activities and glutathione (GSH) levels was observed. The rats were treated to three different ethanol extracts of Myrtle berries (0.25, 0.5, and 1 g/kg) by oral gavage for 14 days. At the end of the experiment, ALT, AST, MDA, and blood glucose levels of the rats significantly decreased while significant increases in GSH levels and SOD activities were observed.We believe that our findings may contribute to the development of new drugs in the treatment of many global disorders due to the antioxidant activity of the ethanol extract of Myrtus communis L. berries.
链脲佐菌素（STZ）是一种抗肿瘤抗生素，用于治疗转移性胰岛细胞瘤。它也被用作创建实验性糖尿病模型的工具。高剂量的 STZ 会对人类和其他哺乳动物的细胞造成严重损害。本研究的目的是评估桃金娘（Myrtus communis L.）浆果的乙醇提取物的保护作用，由于其丰富的酚类含量和对健康的有益影响，桃金娘是一种众所周知的药用植物，可防止 STZ 诱导的糖尿病大鼠的氧化应激。
糖尿病通过 STZ（40mg/kg，ip）在大鼠中诱导。糖尿病诱导后，丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、丙二醛（MDA）和血糖水平显著升高，而超氧化物歧化酶（SOD）活性和谷胱甘肽（GSH）水平显著降低。大鼠通过口服灌胃接受三种不同剂量的桃金娘浆果乙醇提取物（0.25、0.5 和 1g/kg）治疗 14 天。实验结束时，大鼠的 ALT、AST、MDA 和血糖水平显著降低，而 GSH 水平和 SOD 活性显著升高。
我们认为，由于 Myrtus communis L.浆果的乙醇提取物具有抗氧化活性，我们的发现可能有助于开发治疗许多全球疾病的新药。
