Cyclosporine affects the function of antigen-presenting cells.
作者信息
Varey A M, Champion B R, Cooke A
出版信息
Immunology. 1986 Jan;57(1):111-4.
Abstract
The immunosuppressant drug cyclosporine (CsA) is known to affect T-cell function. We have studied the effect of CsA on the specific proliferative response of T-cell lines to antigen. In addition to blocking IL-2 release by specifically activated T-cell lines, CsA also affected the ability of irradiated spleen cells to present preprocessed antigen to T-cell lines. Irradiated spleen cells pulsed with antigen for 2 hr were able to stimulate a proliferative response in T-cell lines. Following a 2-hr pulse with CsA, antigen presentation by these irradiated spleen cells was reduced significantly, suggesting that CsA not only affects T cells, but also affects the function of antigen-presenting cells.
摘要
相似文献
1
Cyclosporine affects the function of antigen-presenting cells.
Immunology. 1986 Jan;57(1):111-4.
2
Cyclosporine inhibits macrophage-mediated antigen presentation.
J Immunol. 1986 Jun 15;136(12):4348-53.
3
Inhibition of the accessory function of murine macrophages in vitro by cyclosporine.
Transplantation. 1985 Jun;39(6):644-9. doi: 10.1097/00007890-198506000-00014.
4
Cyclosporine A inhibits accessory cell and antigen-presenting cell functions of epidermal Langerhans cells.
Transplant Proc. 1988 Apr;20(2 Suppl 2):87-91.
5
Direct antiproliferative effects of cyclosporin A on murine lymphoreticular tumor cells in culture.
J Biol Response Mod. 1983;2(2):121-32.
6
7
Mechanism of action of Cyclosporin A: inhibition of lymphokine secretion studied with antigen-stimulated T cell hybridomas.
J Immunol. 1984 Dec;133(6):3107-11.
8
9
delta 9-Tetrahydrocannabinol modulates antigen processing by macrophages.
J Pharmacol Exp Ther. 1995 Jun;273(3):1216-23.
引用本文的文献
1
Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production.
Inflamm Res. 1996 Apr;45(4):159-65. doi: 10.1007/BF02285155.
2
Effect of cyclosporine on distribution of macrophage subpopulations in rat hepatic allograft.
Dig Dis Sci. 1993 Apr;38(4):619-25. doi: 10.1007/BF01316790.
3
Cyclosporin A enhances elimination of intracellular L. major parasites by murine macrophages.
Clin Exp Immunol. 1989 Jan;75(1):141-6.
4
A complex component modulating immune-deficient cells in leprosy patients leading to loss of viability of Mycobacterium leprae--a possible vaccine.
Clin Exp Immunol. 1990 Jan;79(1):7-14. doi: 10.1111/j.1365-2249.1990.tb05119.x.
5
Lack of demonstrable effect of cyclosporin A on human epidermal Langerhans cell function.
Arch Dermatol Res. 1991;283(3):198-202. doi: 10.1007/BF00372062.
6
Antigen presentation and HLA-DR expression by FK-506-treated human monocytes.
Immunology. 1990 Dec;71(4):551-5.
7
Immunosuppressive activity of FK-506 in rats: flow cytometric analysis of lymphocyte populations in blood, spleen and thymus during treatment and following drug withdrawal.
Clin Exp Immunol. 1990 Jan;79(1):109-14. doi: 10.1111/j.1365-2249.1990.tb05136.x.
本文引用的文献
1
Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.
Eur J Immunol. 1981 Aug;11(8):657-61. doi: 10.1002/eji.1830110812.
2
Differential effects of cyclosporin-A on lymphocyte subpopulations.
Transplant Proc. 1981 Mar;13(1 Pt 1):405-9.
3
Cyclosporin A inhibits the proliferative response and the generation of helper, suppressor and cytotoxic T-cell functions in the autologous mixed lymphocyte reaction.
Cell Immunol. 1981 Jul 1;61(2):453-62. doi: 10.1016/0008-8749(81)90393-2.
4
5
Cyclosporin A does not prevent expression of Tac antigen, a probable TCGF receptor molecule, on mitogen-stimulated human T cells.
J Immunol. 1983 Jun;130(6):2737-42.
6
Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines.
Immunology. 1983 Feb;48(2):291-9.
7
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.
Proc Natl Acad Sci U S A. 1984 Aug;81(16):5214-8. doi: 10.1073/pnas.81.16.5214.
8
Differential effect of cyclosporin A on the expression of T and B lymphocyte activation antigens.
J Immunol. 1984 Jul;133(1):244-50.
9
A comparison of the stimulatory activities of lymphoid dendritic cells and macrophages in T proliferative responses to various antigens.
J Immunol. 1984 Sep;133(3):1179-84.
10
Analysis of cloned T cell function. I. Dissection of cloned T cell proliferative responses using cyclosporin A.
J Immunol. 1982 Nov;129(5):1865-8.
Zotero 插件