环孢素会影响抗原呈递细胞的功能。
Cyclosporine affects the function of antigen-presenting cells.
作者信息
Varey A M, Champion B R, Cooke A
出版信息
Immunology. 1986 Jan;57(1):111-4.
Abstract
The immunosuppressant drug cyclosporine (CsA) is known to affect T-cell function. We have studied the effect of CsA on the specific proliferative response of T-cell lines to antigen. In addition to blocking IL-2 release by specifically activated T-cell lines, CsA also affected the ability of irradiated spleen cells to present preprocessed antigen to T-cell lines. Irradiated spleen cells pulsed with antigen for 2 hr were able to stimulate a proliferative response in T-cell lines. Following a 2-hr pulse with CsA, antigen presentation by these irradiated spleen cells was reduced significantly, suggesting that CsA not only affects T cells, but also affects the function of antigen-presenting cells.
摘要
免疫抑制剂环孢素（CsA）已知会影响T细胞功能。我们研究了CsA对T细胞系对抗原的特异性增殖反应的影响。除了阻断特异性激活的T细胞系释放白细胞介素-2外，CsA还影响经照射的脾细胞将预处理抗原呈递给T细胞系的能力。用抗原脉冲处理2小时的经照射脾细胞能够刺激T细胞系的增殖反应。在用CsA脉冲处理2小时后，这些经照射脾细胞的抗原呈递显著降低，这表明CsA不仅影响T细胞，还影响抗原呈递细胞的功能。
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