环孢素会影响抗原呈递细胞的功能。
Cyclosporine affects the function of antigen-presenting cells.
作者信息
Varey A M, Champion B R, Cooke A
出版信息
Immunology. 1986 Jan;57(1):111-4.
Abstract
The immunosuppressant drug cyclosporine (CsA) is known to affect T-cell function. We have studied the effect of CsA on the specific proliferative response of T-cell lines to antigen. In addition to blocking IL-2 release by specifically activated T-cell lines, CsA also affected the ability of irradiated spleen cells to present preprocessed antigen to T-cell lines. Irradiated spleen cells pulsed with antigen for 2 hr were able to stimulate a proliferative response in T-cell lines. Following a 2-hr pulse with CsA, antigen presentation by these irradiated spleen cells was reduced significantly, suggesting that CsA not only affects T cells, but also affects the function of antigen-presenting cells.
摘要
免疫抑制剂环孢素（CsA）已知会影响T细胞功能。我们研究了CsA对T细胞系对抗原的特异性增殖反应的影响。除了阻断特异性激活的T细胞系释放白细胞介素-2外，CsA还影响经照射的脾细胞将预处理抗原呈递给T细胞系的能力。用抗原脉冲处理2小时的经照射脾细胞能够刺激T细胞系的增殖反应。在用CsA脉冲处理2小时后，这些经照射脾细胞的抗原呈递显著降低，这表明CsA不仅影响T细胞，还影响抗原呈递细胞的功能。
相似文献
1
Cyclosporine affects the function of antigen-presenting cells.环孢素会影响抗原呈递细胞的功能。
Immunology. 1986 Jan;57(1):111-4.
2
Cyclosporine inhibits macrophage-mediated antigen presentation.
J Immunol. 1986 Jun 15;136(12):4348-53.
3
Inhibition of the accessory function of murine macrophages in vitro by cyclosporine.环孢素对小鼠巨噬细胞体外辅助功能的抑制作用。
Transplantation. 1985 Jun;39(6):644-9. doi: 10.1097/00007890-198506000-00014.
4
Cyclosporine A inhibits accessory cell and antigen-presenting cell functions of epidermal Langerhans cells.环孢素A抑制表皮朗格汉斯细胞的辅助细胞及抗原呈递细胞功能。
Transplant Proc. 1988 Apr;20(2 Suppl 2):87-91.
5
Direct antiproliferative effects of cyclosporin A on murine lymphoreticular tumor cells in culture.
J Biol Response Mod. 1983;2(2):121-32.
6
7
8
9
delta 9-Tetrahydrocannabinol modulates antigen processing by macrophages.δ9-四氢大麻酚调节巨噬细胞的抗原加工。
J Pharmacol Exp Ther. 1995 Jun;273(3):1216-23.
引用本文的文献
1
Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production.环孢素A和氯苯扎利完全预防大鼠佐剂性关节炎的临床症状：淋巴结细胞群体和细胞因子产生的调节
Inflamm Res. 1996 Apr;45(4):159-65. doi: 10.1007/BF02285155.
2
Effect of cyclosporine on distribution of macrophage subpopulations in rat hepatic allograft.环孢素对大鼠肝脏同种异体移植中巨噬细胞亚群分布的影响。
Dig Dis Sci. 1993 Apr;38(4):619-25. doi: 10.1007/BF01316790.
3
Cyclosporin A enhances elimination of intracellular L. major parasites by murine macrophages.环孢菌素A可增强小鼠巨噬细胞对细胞内杜氏利什曼原虫寄生虫的清除作用。
Clin Exp Immunol. 1989 Jan;75(1):141-6.
4
A complex component modulating immune-deficient cells in leprosy patients leading to loss of viability of Mycobacterium leprae--a possible vaccine.一种调节麻风病患者免疫缺陷细胞导致麻风分枝杆菌活力丧失的复杂成分——一种可能的疫苗。
Clin Exp Immunol. 1990 Jan;79(1):7-14. doi: 10.1111/j.1365-2249.1990.tb05119.x.
5
Lack of demonstrable effect of cyclosporin A on human epidermal Langerhans cell function.环孢菌素A对人表皮朗格汉斯细胞功能无明显作用。
Arch Dermatol Res. 1991;283(3):198-202. doi: 10.1007/BF00372062.
6
Antigen presentation and HLA-DR expression by FK-506-treated human monocytes.经FK-506处理的人单核细胞的抗原呈递及HLA-DR表达
Immunology. 1990 Dec;71(4):551-5.
7
Immunosuppressive activity of FK-506 in rats: flow cytometric analysis of lymphocyte populations in blood, spleen and thymus during treatment and following drug withdrawal.FK-506对大鼠的免疫抑制活性：治疗期间及停药后血液、脾脏和胸腺中淋巴细胞群体的流式细胞术分析
Clin Exp Immunol. 1990 Jan;79(1):109-14. doi: 10.1111/j.1365-2249.1990.tb05136.x.
本文引用的文献
1
Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.环孢素A通过损害白细胞介素1和白细胞介素2的释放来介导对原发性细胞毒性T细胞反应的免疫抑制。
Eur J Immunol. 1981 Aug;11(8):657-61. doi: 10.1002/eji.1830110812.
2
Differential effects of cyclosporin-A on lymphocyte subpopulations.
Transplant Proc. 1981 Mar;13(1 Pt 1):405-9.
3
Cyclosporin A inhibits the proliferative response and the generation of helper, suppressor and cytotoxic T-cell functions in the autologous mixed lymphocyte reaction.环孢菌素A抑制自体混合淋巴细胞反应中的增殖反应以及辅助性、抑制性和细胞毒性T细胞功能的产生。
Cell Immunol. 1981 Jul 1;61(2):453-62. doi: 10.1016/0008-8749(81)90393-2.
4
Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.环孢素A对人淋巴细胞体外反应的影响。I. 环孢素A允许同种异体抗原激活的抑制细胞表达，同时在混合淋巴细胞反应中优先抑制细胞溶解效应淋巴细胞的诱导。
J Immunol. 1980 Jun;124(6):2601-8.
5
6
Cyclosporin A inhibits lymphokine production but not the responses of macrophages to lymphokines.环孢菌素A可抑制淋巴因子的产生，但不影响巨噬细胞对淋巴因子的反应。
Immunology. 1983 Feb;48(2):291-9.
7
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.环孢菌素A在信使核糖核酸转录水平抑制T细胞生长因子基因的表达。
Proc Natl Acad Sci U S A. 1984 Aug;81(16):5214-8. doi: 10.1073/pnas.81.16.5214.
8
Differential effect of cyclosporin A on the expression of T and B lymphocyte activation antigens.环孢素A对T和B淋巴细胞活化抗原表达的差异作用。
J Immunol. 1984 Jul;133(1):244-50.
9
10
Zotero 插件