Department of Health Management, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
Int Immunopharmacol. 2022 Jan;102:108392. doi: 10.1016/j.intimp.2021.108392. Epub 2021 Nov 23.
The outbreak of novel coronavirus disease 2019 (COVID-19) poses a great stress to frontline medical workers. Our previous study indicated that immune cells in the peripheral blood of frontline medical workers changed significantly. However, the dynamic changes of immune cells of frontline medical workers remain unclear. Here, we reported the dynamic changes of lymphocyte subsets in the peripheral blood of 51 frontline medical worker. The frontline medical workers struggling with COVID-19 from February 8 to March 31, 2020. Demographic and clinical data, including routine blood test data were extracted from the electronic health examination record and retrospectively analyzed. The lymphocyte (LYM) count and LYM ratio increased while the monocyte (MONO) ratio, neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and neutrophil (NEUT) ratio in the peripheral blood of frontline medical workers decreased 10 days after struggling with COVID-19. Interestingly, the differences of LYM count, LYM ratio, MONO ratio, NLR, NEUT ratio were more significantly in nurse than doctor. The differences of LYM ratio, NLR and NEUT ratio were more significantly in female than male. However, the changes of LYM count, LYM ratio, MONO ratio, NLR, MLR, NEUT ratio returned to the baseline 10 months after struggling with COVID-19. Together, these data indicated that immune cells in the peripheral blood changed significantly 10 days after struggling with COVID-19, but returned to normal after 10 months. Those maybe caused by psychological stress and we recommend to pay more attention to mental health and immune response of frontline medical workers.
新型冠状病毒病 2019（COVID-19）的爆发给一线医务人员带来了巨大的压力。我们之前的研究表明，一线医务人员外周血中的免疫细胞发生了明显变化。然而，一线医务人员免疫细胞的动态变化尚不清楚。在这里，我们报告了 51 名一线医务人员外周血中淋巴细胞亚群的动态变化。这些一线医务人员于 2020 年 2 月 8 日至 3 月 31 日与 COVID-19 作斗争。从电子体检记录中提取人口统计学和临床数据，包括常规血液检查数据，并进行回顾性分析。与 COVID-19 作斗争 10 天后，一线医务人员外周血中淋巴细胞（LYM）计数和 LYM 比值升高，而单核细胞（MONO）比值、中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）和中性粒细胞（NEUT）比值降低。有趣的是，护士的 LYM 计数、LYM 比值、MONO 比值、NLR 和 NEUT 比值差异比医生更显著。女性的 LYM 比值、NLR 和 NEUT 比值差异比男性更显著。然而，与 COVID-19 作斗争 10 个月后，LYM 计数、LYM 比值、MONO 比值、NLR、MLR 和 NEUT 比值恢复到基线。总之，这些数据表明，与 COVID-19 作斗争 10 天后，外周血中的免疫细胞发生了明显变化，但 10 个月后恢复正常。这些变化可能是由心理压力引起的，我们建议更多地关注一线医务人员的心理健康和免疫反应。
