Yang Juanjuan, Wang Qian, Jiang Wei
Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Psychiatry. 2023 Jun 15;14:1198734. doi: 10.3389/fpsyt.2023.1198734. eCollection 2023.
There are bidirectional associations between immunological dysfunction and psychiatric symptoms. However, the associations between the levels of immune cells in the peripheral blood and psychiatric symptoms remain unclear. The present study aimed to evaluate levels of immune cells in peripheral blood in people with positive psychiatric symptoms.
This retrospective study analyzed data from routine blood tests and psychopathology and sleep quality assessments. Data were compared between a group of 45 patients with psychological symptoms and 225 matched controls.
Patients with psychiatric symptoms had higher white blood cell and neutrophil counts compared with controls. However, in a subgroup analysis, neutrophil counts were significantly higher than in controls only in patients with multiple psychiatric symptoms. Furthermore, monocyte counts were significantly higher in patients with multiple psychiatric symptoms than in controls. Further, sleep quality was lower in patients with psychiatric symptoms than in controls.
White blood cell and neutrophil counts in the peripheral blood of patients with psychiatric symptoms were significantly higher and sleep quality was significantly lower than in controls. Participants with multiple psychiatric symptoms showed more significant differences in peripheral blood immune cell counts than other subgroups. These results provided evidence for the relationship between psychiatric symptoms, immunity, and sleep.
免疫功能障碍与精神症状之间存在双向关联。然而，外周血中免疫细胞水平与精神症状之间的关联仍不明确。本研究旨在评估有阳性精神症状者外周血中的免疫细胞水平。
这项回顾性研究分析了常规血液检查、精神病理学和睡眠质量评估的数据。对一组45例有心理症状的患者和225例匹配的对照组的数据进行了比较。
与对照组相比，有精神症状的患者白细胞和中性粒细胞计数更高。然而，在亚组分析中，仅在有多种精神症状的患者中，中性粒细胞计数显著高于对照组。此外，有多种精神症状的患者单核细胞计数显著高于对照组。而且，有精神症状的患者睡眠质量低于对照组。
有精神症状的患者外周血白细胞和中性粒细胞计数显著高于对照组，睡眠质量显著低于对照组。有多种精神症状的参与者在外周血免疫细胞计数上比其他亚组表现出更显著的差异。这些结果为精神症状、免疫和睡眠之间的关系提供了证据。
