Coronavirus disease 2019 (COVID-19) is a world-wide epidemic and efficient prevention and control of this disease has become the focus of global scientific communities. In this paper, a novel face mask detection framework FMD-Yolo is proposed to monitor whether people wear masks in a right way in public, which is an effective way to block the virus transmission. In particular, the feature extractor employs Im-Res2Net-101 which combines Res2Net module and deep residual network, where utilization of hierarchical convolutional structure, deformable convolution and non-local mechanisms enables thorough information extraction from the input. Afterwards, an enhanced path aggregation network En-PAN is applied for feature fusion, where high-level semantic information and low-level details are sufficiently merged so that the model robustness and generalization ability can be enhanced. Moreover, localization loss is designed and adopted in model training phase, and Matrix NMS method is used in the inference stage to improve the detection efficiency and accuracy. Benchmark evaluation is performed on two public databases with the results compared with other eight state-of-the-art detection algorithms. At  = 0.5 level, proposed FMD-Yolo has achieved the best precision 50 of 92.0% and 88.4% on the two datasets, and 75 at  = 0.75 has improved 5.5% and 3.9% respectively compared with the second one, which demonstrates the superiority of FMD-Yolo in face mask detection with both theoretical values and practical significance.