Sandor E V, Millman A, Croxson T S, Mildvan D
Am J Ophthalmol. 1986 Feb 15;101(2):153-5. doi: 10.1016/0002-9394(86)90585-4.
In a prospective investigation of 54 consecutive cases of herpes zoster ophthalmicus, conducted over a two-year period, immunologic evaluations included enumeration of T lymphocyte subsets and serum immunoglobulin levels. Herpes zoster ophthalmicus occurred with frequent ocular complications in a subgroup of adults distinguishable by their young age, the presence of AIDS-risk factors, alterations in T-cell subpopulations, and polyclonal increases of serum gammaglobulin. Over the study duration, 21% (three of 14) of the AIDS-risk subgroup patients have developed AIDS with a 14% (two of 14) mortality. Herpes zoster ophthalmicus in AIDS-risk group members appeared to be an early clinical marker for the immune deficiency induced by AIDS retroviral infection.
在一项为期两年的对54例连续性眼带状疱疹病例的前瞻性研究中，免疫评估包括T淋巴细胞亚群计数和血清免疫球蛋白水平测定。眼带状疱疹在一个特定的成年亚组中常伴有眼部并发症，该亚组的特点是年龄较轻、存在艾滋病危险因素、T细胞亚群改变以及血清丙种球蛋白多克隆性升高。在研究期间，艾滋病危险亚组患者中有21%（14例中的3例）发展为艾滋病，死亡率为14%（14例中的2例）。艾滋病危险组成员中的眼带状疱疹似乎是艾滋病逆转录病毒感染所致免疫缺陷的一个早期临床标志。
