Seiff S R, Margolis T, Graham S H, O'Donnell J J
Department of Ophthalmology, San Francisco General Hospital, California.
Ann Ophthalmol. 1988 Dec;20(12):480-2.
Patients who are homosexual, intravenous drug abusers, or have received multiple blood transfusions are at greater risk to contract the immunosuppressive disorders of acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC). These persons also have a greater chance of developing serious neurologic complications after an episode of Herpes zoster. We present two cases which emphasize the serious complications of Herpes zoster ophthalmicus in such patients. Since systemically administered acyclovir may shorten the disease course and reduce the complications of Herpes zoster in immunocompromised individuals, the authors favor treatment of all such patients who have Herpes zoster ophthalmicus with a seven-day course of high-dose (30 mg/kg/day) intravenous acyclovir. To minimize serious neurologic complications in such patients, treatment should be instituted immediately before the results of human immunodeficiency virus (HIV) testing are known.
同性恋患者、静脉吸毒者或接受过多次输血的患者感染获得性免疫缺陷综合征（艾滋病）及艾滋病相关综合征（ARC）等免疫抑制性疾病的风险更高。这些人在患带状疱疹后发生严重神经并发症的几率也更大。我们报告两例病例，强调此类患者眼部带状疱疹的严重并发症。由于全身应用阿昔洛韦可能缩短免疫功能低下个体带状疱疹的病程并减少并发症，作者主张对所有眼部带状疱疹患者采用高剂量（30mg/kg/天）静脉注射阿昔洛韦进行为期7天的治疗。为使此类患者的严重神经并发症降至最低，应在人类免疫缺陷病毒（HIV）检测结果出来之前立即开始治疗。
