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两种新化学型的菊苣属植物精油的化学成分与生物活性

Chemical composition and biological activities of essential oils of two new chemotypes of Glebionis Cass.

作者信息

Servi Hüseyin

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Istanbul Yeni Yüzyıl University, İstanbul Turkey.

出版信息

Turk J Chem. 2021 Oct 19;45(5):1559-1566. doi: 10.3906/kim-2104-11. eCollection 2021.

Abstract

This paper includes the result of the first study of the chemical composition, antioxidant, antiinflammatory, and antidiabetic activities of the essential oils of (L.) Cass. ex Spach and (L.) Fourr. from Turkey. In the current study, nine and twenty-eight constituents were determined in the essential oils of aerial parts of . (GCE) (92.1%) and . (GSE) (90.0%), respectively. The main components were capillin (65.9%) in GCE, capillene (53.4%) in GSE. The essential oil compositions were evaluated and compared with previous researches. In the current study, the plants are classified as chemotypes of species. GCE and GSE showed poor and very poor DPPH radical scavenging activity, respectively. GCE and GSE exhibited significant and strong antiinflammatory activity against the 5-lipoxygenase enzyme, respectively. Also, GCE and GSE displayed moderate and weak antidiabetic activity against the α-glucosidase enzyme, respectively. Polyacetylenes were determined as the main class of compounds in GCE and GSE and had a notable antiinflammatory activity.

摘要

本文包含了对来自土耳其的(L.)Cass. ex Spach和(L.)Fourr.的精油的化学成分、抗氧化、抗炎和抗糖尿病活性的首次研究结果。在当前研究中,分别在(GCE)地上部分的精油中确定了9种成分,在(GSE)地上部分的精油中确定了28种成分,其含量分别为92.1%和90.0%。GCE的主要成分是卡皮林(65.9%),GSE的主要成分是卡皮烯(53.4%)。对精油成分进行了评估并与先前的研究进行了比较。在当前研究中,这些植物被归类为该物种的化学型。GCE和GSE分别表现出较差和非常差的DPPH自由基清除活性。GCE和GSE分别对5-脂氧合酶表现出显著和强烈的抗炎活性。此外,GCE和GSE分别对α-葡萄糖苷酶表现出中等和较弱的抗糖尿病活性。聚乙炔被确定为GCE和GSE中的主要化合物类别,并且具有显著抗炎活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b140/8596538/86000742f9f6/turkjchem-45-1559-fig001.jpg

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