类风湿关节炎中血浆C3d浓度、血清类风湿因子、免疫复合物及C反应蛋白之间的相关性以及与疾病活动临床特征的相关性。
Correlation in rheumatoid arthritis of concentrations of plasma C3d, serum rheumatoid factor, immune complexes and C-reactive protein with each other and with clinical features of disease activity.
作者信息
Mallya R K, Vergani D, Tee D E, Bevis L, de Beer F C, Berry H, Hamilton E D, Mace B E, Pepys M B
出版信息
Clin Exp Immunol. 1982 Jun;48(3):747-53.
Abstract
The concentrations of C3d in the plasma and of C-reactive protein (CRP), immune complexes and rheumatoid factor in the serum were measured in 99 patients with rheumatoid arthritis. Most patients had raised levels, the values of which correlated with disease activity assessed according to a newly described index based on multivariate analysis of subjective, semi-objective and objective features of the disease. There were also significant correlations between the values for plasma C3d and circulating immune complexes, immune complexes and rheumatoid factor, serum CRP and immune complexes, and serum CRP and plasma C3d. Measurement of plasma C3d provides a useful means of detecting in vivo complement activation, which may be involved in the pathogenesis of rheumatoid arthritis, but neither C3d levels nor any of the other variables correlated as closely with disease activity as did the serum CRP concentration.
摘要
对99例类风湿性关节炎患者测定了血浆中C3d的浓度以及血清中C反应蛋白（CRP）、免疫复合物和类风湿因子的浓度。大多数患者这些指标水平升高，其数值与根据基于对该疾病主观、半客观和客观特征进行多变量分析的新描述指数评估的疾病活动度相关。血浆C3d值与循环免疫复合物、免疫复合物与类风湿因子、血清CRP与免疫复合物以及血清CRP与血浆C3d之间也存在显著相关性。血浆C3d的测定为检测体内补体激活提供了一种有用的方法，补体激活可能参与类风湿性关节炎的发病机制，但C3d水平以及任何其他变量与疾病活动度的相关性都不如血清CRP浓度密切。
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