结直肠癌免疫抑制细胞的筛选及预后标志物的鉴定述评
Commentary on: Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers.
机构信息
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.
Centre for Inflammatory Bowel Disease, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Biosci Rep. 2021 Dec 22;41(12). doi: 10.1042/BSR20211096.
Colorectal adenocarcinoma (COAD) is one subtype of colorectal carcinoma (CRC), whose development is associated with genetics, inappropriate immune response, and environmental factors. Although significant advances have been made in the treatment of COAD, the mortality rate remains high. It is a pressing need to explore novel therapeutic targets of COAD. Available evidence indicated that immune cell infiltration was correlated with cancer prognosis. To reveal the roles of immune cells in the COAD prognosis, a study published in Bioscience Reports by Li et al. (Bioscience Reports (2021) 41, https://doi.org/10.1042/BSR20203496) analyzed data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset. It demonstrated a beneficial effect of Th17 cells in COAD prognosis. In addition, six hub genes (KRT23, ULBP2, ASRGL1, SERPINA1, SCIN, and SLC28A2) were identified to correlate with Th17 cells and COAD prognosis, suggesting one new therapy strategy and some predictive biomarkers of COAD. These findings reported by Li et al. may pave one way to explore the molecular mechanism of COAD further.
结直肠癌（CRC）是结直肠腺癌（COAD）的一种亚型，其发展与遗传、免疫反应异常和环境因素有关。尽管在 COAD 的治疗方面取得了显著进展，但死亡率仍然很高。探索 COAD 的新型治疗靶点迫在眉睫。有证据表明，免疫细胞浸润与癌症预后相关。为了揭示免疫细胞在 COAD 预后中的作用，Li 等人在 Bioscience Reports 上发表的一项研究（Bioscience Reports (2021) 41, https://doi.org/10.1042/BSR20203496）分析了来自癌症基因组图谱（TCGA）和基因表达综合数据库（GEO）的数据。结果表明，Th17 细胞对 COAD 的预后有益。此外，还鉴定出 6 个与 Th17 细胞和 COAD 预后相关的关键基因（KRT23、ULBP2、ASRGL1、SERPINA1、SCIN 和 SLC28A2），提示 COAD 的一种新的治疗策略和一些预测性生物标志物。Li 等人的这些发现可能为进一步探索 COAD 的分子机制开辟了一条道路。
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