Vollmer E, Shimamoto F, Krieg V, Grundmann E
J Cancer Res Clin Oncol. 1986;111(1):13-9. doi: 10.1007/BF00402769.
Ascites tumor cells (2 X 10(6] of a DMBA-induced rat mammary adenocarcinoma (HH9-cl 14) were injected s.c. into tumor-free syngeneic female rats and produced a continuously growing solid tumor in all animals of this group. Inoculation of 2 X 10(7) cells induced a first brief period of tumor growth, followed by complete tumor regression from the 2nd until the 5th week after injection. Both the progressive and the regressive tumors were analyzed immunohistologically at different stages with monoclonal antibodies against different T lymphocytes and macrophages. Obviously these cells appear in different quantity and quality, during the hosts immune response. Possible interactions of T lymphocytes and macrophages with tumor cells are discussed.
将腹水肿瘤细胞（2×10⁶个DMBA诱导的大鼠乳腺腺癌（HH9-cl 14））皮下注射到无肿瘤的同基因雌性大鼠体内，该组所有动物均产生了持续生长的实体瘤。接种2×10⁷个细胞诱导了肿瘤生长的第一个短暂时期，随后在注射后第2周至第5周肿瘤完全消退。在不同阶段用针对不同T淋巴细胞和巨噬细胞的单克隆抗体对进行性肿瘤和消退性肿瘤进行免疫组织学分析。显然，在宿主免疫反应过程中，这些细胞在数量和质量上均有所不同。讨论了T淋巴细胞和巨噬细胞与肿瘤细胞之间可能的相互作用。
