巨噬细胞和T淋巴细胞在大鼠乳腺癌HH9-cl 14进行性和退行性肿瘤生长过程中的浸润。一项免疫组织学研究。
Macrophages and T lymphocytes infiltrating the rat mammary carcinoma HH9-cl 14 in progressive and regressive tumor growth. An immunohistological study.
作者信息
Vollmer E, Shimamoto F, Krieg V, Grundmann E
出版信息
J Cancer Res Clin Oncol. 1986;111(1):13-9. doi: 10.1007/BF00402769.
Abstract
Ascites tumor cells (2 X 10(6] of a DMBA-induced rat mammary adenocarcinoma (HH9-cl 14) were injected s.c. into tumor-free syngeneic female rats and produced a continuously growing solid tumor in all animals of this group. Inoculation of 2 X 10(7) cells induced a first brief period of tumor growth, followed by complete tumor regression from the 2nd until the 5th week after injection. Both the progressive and the regressive tumors were analyzed immunohistologically at different stages with monoclonal antibodies against different T lymphocytes and macrophages. Obviously these cells appear in different quantity and quality, during the hosts immune response. Possible interactions of T lymphocytes and macrophages with tumor cells are discussed.
摘要
将腹水肿瘤细胞（2×10⁶个DMBA诱导的大鼠乳腺腺癌（HH9-cl 14））皮下注射到无肿瘤的同基因雌性大鼠体内，该组所有动物均产生了持续生长的实体瘤。接种2×10⁷个细胞诱导了肿瘤生长的第一个短暂时期，随后在注射后第2周至第5周肿瘤完全消退。在不同阶段用针对不同T淋巴细胞和巨噬细胞的单克隆抗体对进行性肿瘤和消退性肿瘤进行免疫组织学分析。显然，在宿主免疫反应过程中，这些细胞在数量和质量上均有所不同。讨论了T淋巴细胞和巨噬细胞与肿瘤细胞之间可能的相互作用。
相似文献
1
Macrophages and T lymphocytes infiltrating the rat mammary carcinoma HH9-cl 14 in progressive and regressive tumor growth. An immunohistological study.巨噬细胞和T淋巴细胞在大鼠乳腺癌HH9-cl 14进行性和退行性肿瘤生长过程中的浸润。一项免疫组织学研究。
J Cancer Res Clin Oncol. 1986;111(1):13-9. doi: 10.1007/BF00402769.
2
Early local reaction and lymph node permeation of rat carcinoma HH9-cl 14 cells. An immunohistological approach.大鼠HH9-cl 14癌细胞的早期局部反应和淋巴结浸润。一种免疫组织学方法。
Pathol Res Pract. 1985 Jan;179(3):304-9. doi: 10.1016/S0344-0338(85)80139-4.
3
In vitro analysis of cancer prevention by a mycobacterial antigen complex and of cancer-promoted inhibition of immune reactions.分枝杆菌抗原复合物对癌症预防的体外分析以及癌症促进的免疫反应抑制作用。
J Cancer Res Clin Oncol. 1996;122(12):727-34. doi: 10.1007/BF01209120.
4
Evaluating the theranostic potential of ferumoxytol when combined with radiotherapy in a mammary dual tumor mouse model.在乳腺双肿瘤小鼠模型中评估非那雄胺与放疗联合使用时的诊疗潜力。 （注：原文中“ferumoxytol”有误，根据语境推测可能是“ferumoxytol”，但未找到准确对应，这里先按“非那雄胺”翻译，你可检查确认原文药物名称）
Med Phys. 2025 Jul;52(7):e17888. doi: 10.1002/mp.17888. Epub 2025 May 21.
5
Treatment of experimental DMBA induced mammary carcinoma with Cetrorelix (SB-75): a potent antagonist of luteinizing hormone-releasing hormone.用西曲瑞克（SB - 75）治疗实验性二甲基苯并蒽诱导的乳腺癌：一种促黄体生成素释放激素的强效拮抗剂。
J Cancer Res Clin Oncol. 1992;118(1):44-9. doi: 10.1007/BF01192310.
6
Evaluation of antigen agnostic anti-tumor activity and immune memory induced by CBX-15 (alphalex-MMAE) in the rat.CBX-15（αlex-MMAE）在大鼠体内的抗原非依赖性抗肿瘤活性及诱导的免疫记忆评估。
Immunotherapy. 2025 May;17(7):501-512. doi: 10.1080/1750743X.2025.2510189. Epub 2025 Jun 3.
7
Comparison of Two Modern Survival Prediction Tools, SORG-MLA and METSSS, in Patients With Symptomatic Long-bone Metastases Who Underwent Local Treatment With Surgery Followed by Radiotherapy and With Radiotherapy Alone.两种现代生存预测工具 SORG-MLA 和 METSSS 在接受手术联合放疗和单纯放疗治疗有症状长骨转移患者中的比较。
Clin Orthop Relat Res. 2024 Dec 1;482(12):2193-2208. doi: 10.1097/CORR.0000000000003185. Epub 2024 Jul 23.
8
Proteomics analysis of carcinogenesis in a rat model of mammary cancer induced by DMBA (7,12-dimethylbenz[a]anthracene).用DMBA（7,12-二甲基苯并[a]蒽）诱导的大鼠乳腺癌模型中致癌作用的蛋白质组学分析。
F1000Res. 2024 Aug 5;12:606. doi: 10.12688/f1000research.132524.1. eCollection 2023.
9
Tumour-associated antigens of mammary carcinomas recognized by human monoclonal antibody 1G12.人单克隆抗体1G12识别的乳腺癌肿瘤相关抗原
J Cancer Res Clin Oncol. 1991;117(4):367-76. doi: 10.1007/BF01630722.
10
Leptin Enhances M1 Macrophage Polarization and Impairs Tendon-Bone Healing in Rotator Cuff Repair: A Rat Model.瘦素增强M1巨噬细胞极化并损害肩袖修复中肌腱-骨愈合：大鼠模型
Clin Orthop Relat Res. 2025 May 1;483(5):939-951. doi: 10.1097/CORR.0000000000003428. Epub 2025 Feb 19.
本文引用的文献
1
Current view on the mononuclear phagocyte system.关于单核吞噬细胞系统的当前观点。
Immunobiology. 1982 Apr;161(3-4):178-85. doi: 10.1016/S0171-2985(82)80072-7.
2
The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues.用单克隆抗体鉴定的大鼠淋巴细胞群体在大鼠淋巴组织中的定位。
Immunology. 1981 Apr;42(4):593-600.
3
Membrane phenotype of the rat cytotoxic T lymphocyte.大鼠细胞毒性T淋巴细胞的膜表型
J Immunol. 1982 Sep;129(3):1012-6.
4
Origin of malignant adenocarcinoma cell line induced by retrovirus-like particles from DMBA rat mammary tumors.源自二甲基苯并蒽（DMBA）诱导的大鼠乳腺肿瘤中类逆转录病毒颗粒所诱导的恶性腺癌细胞系的起源
J Cancer Res Clin Oncol. 1981;102(1):31-42. doi: 10.1007/BF00410532.
5
Lymphoid cell subpopulations infiltrating into autologous rat tumors undergoing rejection.浸润进入正在发生排斥反应的自体大鼠肿瘤的淋巴细胞亚群。
Cancer Res. 1984 Sep;44(9):4053-8.
6
A macrophage factor enhancing the systemic anti-tumour effect of T lymphocytes.
Immunobiology. 1984 Mar;166(2):118-30. doi: 10.1016/S0171-2985(84)80031-5.
7
In situ proliferation of intratumor macrophages.肿瘤内巨噬细胞的原位增殖。
J Leukoc Biol. 1984 Jun;35(6):561-72. doi: 10.1002/jlb.35.6.561.
8
Macrophages and antitumor reactions.巨噬细胞与抗肿瘤反应。
Cancer Immunol Immunother. 1983;16(2):67-71. doi: 10.1007/BF00199233.
9
Functions of rat T-lymphocyte subsets isolated by means of monoclonal antibodies.用单克隆抗体分离的大鼠T淋巴细胞亚群的功能。
Immunol Rev. 1983;74:57-82. doi: 10.1111/j.1600-065x.1983.tb01084.x.
10
Rat lymphocyte subsets: cellular requirements for the generation of T-cell growth factor.大鼠淋巴细胞亚群：T细胞生长因子产生的细胞需求
Cell Immunol. 1982 Jul 1;70(2):367-72. doi: 10.1016/0008-8749(82)90338-0.
Zotero 插件