源自二甲基苯并蒽（DMBA）诱导的大鼠乳腺肿瘤中类逆转录病毒颗粒所诱导的恶性腺癌细胞系的起源
Origin of malignant adenocarcinoma cell line induced by retrovirus-like particles from DMBA rat mammary tumors.
作者信息
Hölzel F, Sakuma S, Hanke D
出版信息
J Cancer Res Clin Oncol. 1981;102(1):31-42. doi: 10.1007/BF00410532.
Abstract
Intraperitoneal inoculation of neonate Sprague Dawley rats with cell-free extracts containing retrovirus-like particles from DMBA-induced rat mammary tumors resulted in a fivefold increase of benign mammary neoplasias in the survivor animals, in comparison to the spontaneous tumor incidence rate. In addition, four animals developed metastasizing abdominal adenocarcinomas. The ascitic cells of one of the abdominal tumors were established as a permanent tissue culture line (HH-1). After subsequent animal passage, cells of the permanent line HH-9 clone 14 showed increased malignancy manifested by the number of takes per animals injected, and by the number of remote metastases observed.
摘要
用含有来自二甲基苯并蒽（DMBA）诱导的大鼠乳腺肿瘤的逆转录病毒样颗粒的无细胞提取物对新生斯普拉格-道利大鼠进行腹腔接种，与自发肿瘤发生率相比，存活动物的良性乳腺肿瘤增加了五倍。此外，四只动物发生了转移性腹部腺癌。其中一个腹部肿瘤的腹水细胞被建立为永久性组织培养系（HH-1）。在随后的动物传代后，永久性系HH-9克隆14的细胞显示出恶性程度增加，表现为每只注射动物的接种成功率以及观察到的远处转移数量。
相似文献
1
Origin of malignant adenocarcinoma cell line induced by retrovirus-like particles from DMBA rat mammary tumors.源自二甲基苯并蒽（DMBA）诱导的大鼠乳腺肿瘤中类逆转录病毒颗粒所诱导的恶性腺癌细胞系的起源
J Cancer Res Clin Oncol. 1981;102(1):31-42. doi: 10.1007/BF00410532.
2
Proteomics analysis of carcinogenesis in a rat model of mammary cancer induced by DMBA (7,12-dimethylbenz[a]anthracene).用DMBA（7,12-二甲基苯并[a]蒽）诱导的大鼠乳腺癌模型中致癌作用的蛋白质组学分析。
F1000Res. 2024 Aug 5;12:606. doi: 10.12688/f1000research.132524.1. eCollection 2023.
3
Site of origin of mammary tumors induced by 7,12-dimethylbenz(a)anthracene in the rat.7,12-二甲基苯并(a)蒽诱导大鼠乳腺肿瘤的起源部位。
J Natl Cancer Inst. 1975 Apr;54(4):1007-9.
4
Treatment of experimental DMBA induced mammary carcinoma with Cetrorelix (SB-75): a potent antagonist of luteinizing hormone-releasing hormone.用西曲瑞克（SB - 75）治疗实验性二甲基苯并蒽诱导的乳腺癌：一种促黄体生成素释放激素的强效拮抗剂。
J Cancer Res Clin Oncol. 1992;118(1):44-9. doi: 10.1007/BF01192310.
5
Expression of RNA of an endogenous replication-defective retrovirus in rat mammary adenocarcinomas induced by 7,12-dimethylbenz[a]anthracene.7,12-二甲基苯并[a]蒽诱导的大鼠乳腺腺癌中内源性复制缺陷型逆转录病毒RNA的表达
J Natl Cancer Inst. 1978 Nov;61(5):1329-37. doi: 10.1093/jnci/61.5.1329.
6
Schizophyllan inhibits the development of mammary and hepatic carcinomas induced by 7,12 dimethylbenz(α)anthracene and decreases cell proliferation: comparison with tamoxifen.裂褶菌多糖抑制 7,12-二甲基苯并蒽诱导的乳腺癌和肝癌的发展，并降低细胞增殖：与他莫昔芬的比较。
J Cancer Res Clin Oncol. 2012 Sep;138(9):1579-96. doi: 10.1007/s00432-012-1224-0. Epub 2012 May 3.
7
Topographical distribution of dimethylbenz(a)anthracene-induced rat mammary tumors.二甲基苯并(a)蒽诱导的大鼠乳腺肿瘤的拓扑分布。
Ann Clin Lab Sci. 1983 Jul-Aug;13(4):289-90.
8
9
Tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland of dibenzo[a]pyrenes: the very potent environmental carcinogen dibenzo[a, l]pyrene.二苯并[a]芘在小鼠皮肤中的肿瘤起始活性及在大鼠乳腺中的致癌性：极强的环境致癌物二苯并[a, l]芘。
J Cancer Res Clin Oncol. 1989;115(1):67-72. doi: 10.1007/BF00391602.
10
Ameliorative effect of Astaxanthin on DMBA-induced breast cancer in female rats: Interplay between Notch-1 and related miRNAs.虾青素对二甲基苯并蒽诱导的雌性大鼠乳腺癌的改善作用：Notch-1与相关微小RNA之间的相互作用
Eur J Pharmacol. 2025 Sep 5;1002:177779. doi: 10.1016/j.ejphar.2025.177779. Epub 2025 May 28.
引用本文的文献
1
Macrophages and T lymphocytes infiltrating the rat mammary carcinoma HH9-cl 14 in progressive and regressive tumor growth. An immunohistological study.巨噬细胞和T淋巴细胞在大鼠乳腺癌HH9-cl 14进行性和退行性肿瘤生长过程中的浸润。一项免疫组织学研究。
J Cancer Res Clin Oncol. 1986;111(1):13-9. doi: 10.1007/BF00402769.
本文引用的文献
1
Spontaneous tumors in two colonies of rats of the Wistar Institute of Anatomy and Biology.解剖学与生物学威斯塔研究所的两个大鼠群体中的自发性肿瘤。
Am J Pathol. 1940 May;16(3):237-254.1.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
Mammary tumors of the rat: a review.大鼠乳腺肿瘤：综述
Cancer Res. 1959 Dec;19:1125-39.
4
Spontaneous tumors in the Sprague-Dawley rat.斯普拉格-道利大鼠的自发性肿瘤。
J Natl Cancer Inst. 1961 Nov;27:1037-57.
5
Hormone-producing cultures of adrenal and pituitary tumor origin.源自肾上腺和垂体肿瘤的激素分泌培养物。
Proc Natl Acad Sci U S A. 1962 Jul 15;48(7):1184-90. doi: 10.1073/pnas.48.7.1184.
6
Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.单次喂食多环烃诱导的乳腺癌及其抑制作用。
Nature. 1961 Jan 21;189:204-7. doi: 10.1038/189204a0.
7
Spontaneous tumors in the Rochester strain of the Wistar rat.Wistar大鼠罗切斯特品系中的自发性肿瘤。
Am J Pathol. 1958 Mar-Apr;34(2):311-35.
8
Hormonal influences on mammary tumors of the rat. I. Acceleration of growth of transplanted fibroadenoma in ovariectomized and hypophysectomized rats.激素对大鼠乳腺肿瘤的影响。I. 去卵巢和垂体切除大鼠移植性纤维腺瘤生长的加速
J Exp Med. 1956 Oct 1;104(4):525-38. doi: 10.1084/jem.104.4.525.
9
Tumor incidence in normal Sprague-Dawley female rats.正常斯普拉格-道利雌性大鼠的肿瘤发生率。
Cancer Res. 1956 Mar;16(3):194-7.
10
Origin of retroviruses from cellular moveable genetic elements.逆转录病毒起源于细胞可移动遗传元件。
Cell. 1980 Oct;21(3):599-600. doi: 10.1016/0092-8674(80)90420-1.
Zotero 插件