Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al-Minya, Egypt.
Dermatol Ther. 2022 Feb;35(2):e15239. doi: 10.1111/dth.15239. Epub 2021 Dec 9.
Melasma is a common esthetic problem affecting the face with a lot of risk factors being incriminated. Although several treatment options are available, none of them is satisfactory. This split face prospective study aimed to compare the efficacy of microneedling with vitamin C versus with platelet-rich plasma (PRP) in the management of mixed melasma. Ten females with bilateral mixed facial melasma were treated with six sessions of microneedling. After the needling vitamin C was applied on the right side of the face and PRP was applied on the left side. Clinical, dermoscopic, and histological assessment of the used treatments was done 1 month after the last session. The clinical and dermoscopic clearance of melasma was proved significantly on both sides of the face but was more significant with vitamin C (P = 0.005). Reduction of epidermal melanin and dermal melanophages was more observed with vitamin C. Moreover, MART-1 stain revealed a more significant reduction in the epidermal, dermal, and the total MART-1 positive cells with vitamin C (P = 0.044, 0.039, and 0.035, respectively). Microneedling with vitamin C was more efficient in treating mixed melasma than with PRP.
黄褐斑是一种常见的影响面部美观的问题，有许多危险因素与之相关。虽然有几种治疗选择，但没有一种是令人满意的。本项半脸前瞻性研究旨在比较微针与维生素 C 和富血小板血浆 (PRP) 在混合性黄褐斑治疗中的疗效。10 名女性双侧面部混合性黄褐斑患者接受了 6 次微针治疗。微针治疗后，右侧面部给予维生素 C 治疗，左侧面部给予 PRP 治疗。末次治疗后 1 个月，对所用治疗方法进行临床、皮肤镜和组织学评估。两种治疗方法均可显著改善黄褐斑的临床和皮肤镜表现，但维生素 C 组改善更显著（P=0.005）。维生素 C 治疗可更明显地减少表皮黑色素和真皮黑素细胞。此外，MART-1 染色显示维生素 C 治疗可更显著地减少表皮、真皮和总 MART-1 阳性细胞（P=0.044、0.039 和 0.035）。微针联合维生素 C 治疗混合性黄褐斑的疗效优于 PRP。
