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褪黑素对鸡胚肿瘤异种移植模型中胃癌生长的作用

Activity of Melatonin Against Gastric Cancer Growth in a Chick Embryo Tumor Xenograft Model.

作者信息

Wang Rixiong, Liu Hui, Song Jun, Wu Qing

机构信息

Department of Oncology, the First Affiliated Hospital of Fujian Medical University, Fuzhou City, People's Republic of China.

Fujian Key Laboratory of Precision Medicine for Cancer, the First Affiliated Hospital of Fujian Medical University, Fuzhou City, People's Republic of China.

出版信息

Cancer Manag Res. 2021 Nov 24;13:8803-8808. doi: 10.2147/CMAR.S329728. eCollection 2021.

DOI:10.2147/CMAR.S329728
PMID:34853535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8627858/
Abstract

PURPOSE

Previous studies have shown the antitumor activity of melatonin against a wide range of human cancers; however, the impact of melatonin on gastric cancer growth remains to be illustrated. This study aimed to investigate the activity of melatonin against gastric cancer growth in a chick embryo tumor xenograft model and explore the possible mechanisms.

MATERIALS AND METHODS

The growth of gastric cancer SGC-7901 cells was measured using MTT assay, and a chick embryo tumor xenograft model was generated to observe the effect of melatonin on gastric cancer growth in vivo. In addition, the VEGF and angiogenin secretion was measured in the supernatant of chick embryo tumor xenograft models with ELISA.

RESULTS

MLT treatment inhibited the growth of SGC-7901 cells at a concentration-dependent manner, and treatment with MLT at 1 mM was found to markedly reduce the volume and weight of tumors bearing the allantois of chicken embryos. ELISA showed that MLT at concentrations of 0.0041, 0.012, 0.037 and 0.11 had no remarkable impact on VEGF and angiopoietin secretion, while MLT at 1 mM significantly suppressed VEGF and angiopoietin production in chick embryo tumor xenograft models with SGC-7901 cells ( = 0.023).

CONCLUSION

Our data demonstrate that MLT inhibits gastric cancer growth in vitro at a concentration-dependent manner, and suppresses angiogenesis of the chick embryo tumor xenograft model with SGC-7901 cells through inhibiting VEGF and angiogenin secretion. Further studies are needed to investigate the therapeutic potential of MLT for gastric cancer as compared to drugs clinically approved.

摘要

目的

先前的研究已表明褪黑素对多种人类癌症具有抗肿瘤活性；然而，褪黑素对胃癌生长的影响仍有待阐明。本研究旨在探讨褪黑素在鸡胚肿瘤异种移植模型中对胃癌生长的作用，并探索其可能的机制。

材料与方法

采用MTT法检测胃癌SGC - 7901细胞的生长情况，并建立鸡胚肿瘤异种移植模型以观察褪黑素对体内胃癌生长的影响。此外，用ELISA法检测鸡胚肿瘤异种移植模型上清液中VEGF和血管生成素的分泌情况。

结果

MLT处理以浓度依赖性方式抑制SGC - 7901细胞的生长，发现1 mM的MLT处理可显著降低携带鸡胚尿囊的肿瘤体积和重量。ELISA结果显示，浓度为0.0041、0.012、0.037和0.11的MLT对VEGF和血管生成素的分泌没有显著影响，而1 mM的MLT可显著抑制SGC - 7901细胞鸡胚肿瘤异种移植模型中VEGF和血管生成素的产生（P = 0.023）。

结论

我们的数据表明，MLT在体外以浓度依赖性方式抑制胃癌生长，并通过抑制VEGF和血管生成素的分泌来抑制SGC - 7901细胞鸡胚肿瘤异种移植模型的血管生成。与临床批准的药物相比，MLT对胃癌的治疗潜力还需要进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3e/8627858/7028c0a45274/CMAR-13-8803-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3e/8627858/200b0b766dcc/CMAR-13-8803-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3e/8627858/1fc807d5bb21/CMAR-13-8803-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3e/8627858/7028c0a45274/CMAR-13-8803-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3e/8627858/200b0b766dcc/CMAR-13-8803-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3e/8627858/1fc807d5bb21/CMAR-13-8803-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f3e/8627858/7028c0a45274/CMAR-13-8803-g0003.jpg

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