School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.
ARC Research Hub for Integrated Devices for End-user Analysis at Low-levels (IDEAL), Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.
Methods Mol Biol. 2022;2402:13-20. doi: 10.1007/978-1-0716-1843-1_2.
Monitoring the changes in membrane conductance using electrical impedance spectroscopy is the platform of membrane-based biosensors in order to detect a specific target molecule. These biosensors represent the amalgamation of an electrical conductor such as gold and a chemically tethered bilayer lipid membrane with specific incorporated ion channels such as gramicidin-A that is further functionalized with detector molecules of interest.
利用阻抗谱监测膜电导的变化是基于膜的生物传感器的平台，以检测特定的靶分子。这些生物传感器代表了金等电导体与化学固定的双层脂质膜的融合，其中进一步功能化了具有特定结合的离子通道，如革兰氏菌素-A，以及感兴趣的检测分子。
