Cunningham T J, Medcalf R L, Mathews J D, Muirden K D
Ann Rheum Dis. 1986 Jan;45(1):15-20. doi: 10.1136/ard.45.1.15.
Platelet releasing activity was found in sera fractionated by 30% ammonium sulphate in seven of 11 patients with systemic rheumatoid vasculitis, two of 16 patients with cutaneous rheumatoid vasculitis, and three of 18 patients with clinically uncomplicated rheumatoid arthritis. Serial studies in three patients suggest a key role of platelet activation by serum factors in the pathogenesis of systemic rheumatoid vasculitis. IgG rheumatoid factor or IgG containing immune complexes, or both, may be responsible for this platelet releasing activity.
在11例系统性类风湿性血管炎患者中的7例、16例皮肤类风湿性血管炎患者中的2例以及18例临床症状不复杂的类风湿性关节炎患者中的3例的血清中，发现经30%硫酸铵分级分离后的血清具有血小板释放活性。对3例患者的系列研究表明，血清因子激活血小板在系统性类风湿性血管炎的发病机制中起关键作用。IgG类风湿因子或含IgG的免疫复合物，或两者，可能是这种血小板释放活性的原因。
