Zilberfarb J L, Andrews B S, Young A C, Davis J S
J Rheumatol. 1985 Jun;12(3):444-8.
Clq binding activity (ClqBA) averaged 18.1 +/- 14.5% (1 SD) in 28 rheumatoid arthritis (RA) sera (normal sera = 3.9 +/- 0.4%). Further analysis indicated that rheumatoid factor (RF) positive [RA (+)] sera averaged 30.4% ClqBA, significantly greater than the 3.9% ClqBA in RA RF negative [RA(-)] sera (p less than 0.01). In the RA(+) sera, RF titer correlated with ClqBA (r = +0.73). Addition of IgM RF to sera of normal, SLE, and RA(-) patients, as well as to aggregated IgG and reduced and alkylated aggregated IgG, resulted in significant increases in ClqBA, up to 14% in the latter group (p less than 0.01). Control IgM added to these same systems had no effect on ClqBA. IgM RF only slightly increased Clq binding of monomeric IgG.
在28份类风湿性关节炎（RA）血清中，Clq结合活性（ClqBA）平均为18.1±14.5%（1个标准差）（正常血清=3.9±0.4%）。进一步分析表明，类风湿因子（RF）阳性[RA（+）]血清的ClqBA平均为30.4%，显著高于RA RF阴性[RA（-）]血清中的3.9% ClqBA（p<0.01）。在RA（+）血清中，RF滴度与ClqBA相关（r=+0.73）。向正常、系统性红斑狼疮（SLE）和RA（-）患者的血清中添加IgM RF，以及向聚集的IgG和还原及烷基化的聚集IgG中添加IgM RF，均导致ClqBA显著增加，后一组中增加高达14%（p<0.01）。向这些相同系统中添加对照IgM对ClqBA无影响。IgM RF仅略微增加单体IgG的Clq结合。
