高脂血症与犬草酸钙下尿路结石的关系。

Association between hyperlipidemia and calcium oxalate lower urinary tract uroliths in dogs.

机构信息

Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine-University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Department of Small Animal Clinical Sciences, Veterinary Teaching Hospital-University of Montreal, Saint-Hyacinthe, Quebec, Canada.

出版信息

J Vet Intern Med. 2022 Jan;36(1):146-155. doi: 10.1111/jvim.16324. Epub 2021 Dec 2.

DOI:10.1111/jvim.16324

PMID:34854133

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8783332/

Abstract

BACKGROUND

Metabolic syndrome is associated with formation of calcium oxalate (CaOx) uroliths in humans.

OBJECTIVES

To investigate the association between obesity and hyperlipidemia with CaOx lower urinary tract uroliths in client-owned dogs.

ANIMALS

Dogs with (n = 55, U [uroliths]-dogs) and without (n = 39, UF [uroliths-free]-dogs) CaOx lower urinary tract uroliths.

METHODS

Case-control study. U-dogs were retrospectively enrolled and compared to UF-dogs. Body condition score (BCS; 1-9 scoring scale), serum triglyceride (TG) and total cholesterol (CH) concentrations and glycemia (after >12-hour food withholding) were recorded in both groups.

RESULTS

On univariate logistic regression, when excluding Miniature Schnauzers, odds of having uroliths increased by a factor of 3.32 (95% CI 1.38-11.12) for each mmol/L of TG (P = .027), of 39 (95% CI 9.27-293.22) for each mmol/L of glycemia (P < .0001), and of 2.43 (95% CI 1.45-4.45) per unit of BCS (P = .002). In multivariable models, the effect of TG was retained when all breeds were included for analysis and odds of having uroliths increased by a factor of 4.34 per mmol/L of TG (95% CI 1.45-19.99; P = .02).

CONCLUSIONS AND CLINICAL IMPORTANCE

Serum lipid screening in dogs diagnosed with CaOx uroliths might be recommended to improve their medical staging and management.

摘要

背景

代谢综合征与人类草酸钙（CaOx）尿结石的形成有关。

目的

研究肥胖和高脂血症与犬下尿路草酸钙尿结石的关系。

动物

患有（n=55，U[结石]-犬）和不患有（n=39，UF[无结石]-犬）CaOx 下尿路结石的犬。

方法

病例对照研究。回顾性招募 U-犬，并与 UF-犬进行比较。记录两组犬的体况评分（BCS；1-9 评分）、血清三酰甘油（TG）和总胆固醇（CH）浓度以及血糖（禁食>12 小时后）。

结果

在单变量逻辑回归中，当排除迷你雪纳瑞犬时，TG 每增加 1mmol/L，患结石的几率增加 3.32 倍（95%CI 1.38-11.12；P=0.027），血糖每增加 1mmol/L，患结石的几率增加 39 倍（95%CI 9.27-293.22；P<0.0001），BCS 每增加 1 个单位，患结石的几率增加 2.43 倍（95%CI 1.45-4.45；P=0.002）。在多变量模型中，当所有品种都纳入分析时，TG 的作用仍然保留，TG 每增加 1mmol/L，患结石的几率增加 4.34 倍（95%CI 1.45-19.99；P=0.02）。