Dubé I D, Raimondi S C, Pi D, Kalousek D K
Blood. 1986 Apr;67(4):1181-4.
Four cases of T cell neoplasia are reported: three presenting as T cell acute lymphoblastic leukemia and one presenting in the leukemic phase of a T cell lymphoma. In all cases, the cells of the leukemic clone were characterized by an identical cytogenetic abnormality. This abnormality was a unique reciprocal translocation involving chromosomes 10 and 14. The breakpoint in chromosome 14 was in band q11, coincident with the assigned locus of the alpha-chain gene of the T cell antigen receptor. The breakpoint in chromosome 10 was in band q24, a region reported to include the locus of the terminal deoxynucleotidyltransferase (TdT) gene. Our observations suggest that translocation t(10;14)(q24;q11) is specific for T cell neoplasia and that a gene in chromosomal band 10q24, possibly the TdT gene, plays an important role in T cell neoplasia when its expression or coding sequence is altered by aberrant recombination involving a T cell antigen receptor gene.
报告了4例T细胞肿瘤：3例表现为T细胞急性淋巴细胞白血病，1例表现为T细胞淋巴瘤的白血病期。在所有病例中，白血病克隆细胞具有相同的细胞遗传学异常特征。这种异常是涉及10号和14号染色体的独特相互易位。14号染色体的断点在q11带，与T细胞抗原受体α链基因的指定位点一致。10号染色体的断点在q24带，据报道该区域包括末端脱氧核苷酸转移酶（TdT）基因的位点。我们的观察结果表明，易位t(10;14)(q24;q11)对T细胞肿瘤具有特异性，并且当10q24染色体带中的一个基因（可能是TdT基因）的表达或编码序列因涉及T细胞抗原受体基因的异常重组而改变时，它在T细胞肿瘤中起重要作用。
