肿瘤携带对影响巨噬细胞行为的淋巴因子产生的影响。
Influence of tumour carriage on the production of lymphokines affecting macrophage behaviour.
作者信息
McIntosh L C, Morrice L M, Udagawa Y, Thomson A W
出版信息
Immunology. 1986 Mar;57(3):359-65.
Normal and cyclophosphamide (Cy)-enhanced delayed-type hypersensitivity (DTH) reactions to sheep red blood cells (SRBC) were severely impaired in CD1 mice injected with 10(6) viable Landschütz ascites carcinoma (LAC) cells at the time of immunization. The tumour-induced suppression of DTH was accompanied by inhibition of splenic T-lymphocyte responses to antigen and mitogen. This was assessed by measuring lymphocyte transformation and the production of two lymphokines affecting macrophage behavior, i.e. lymphocyte-derived chemotactic factor (LDCF) and macrophage procoagulant-inducing factor (MPIF). Our results imply that impaired production/function of lymphokines affecting macrophage behaviour may play a key role in tumour-induced suppression of cell-mediated immunity and that this inhibition is independent of Cy-sensitive suppressor cells.
在免疫时注射了10⁶个活的兰施胡茨腹水癌（LAC）细胞的CD1小鼠中，对绵羊红细胞（SRBC）的正常和环磷酰胺（Cy）增强的迟发型超敏反应（DTH）严重受损。肿瘤诱导的DTH抑制伴随着脾T淋巴细胞对抗原和丝裂原反应的抑制。这是通过测量淋巴细胞转化以及两种影响巨噬细胞行为的淋巴因子的产生来评估的，即淋巴细胞衍生趋化因子（LDCF）和巨噬细胞促凝诱导因子（MPIF）。我们的结果表明，影响巨噬细胞行为的淋巴因子产生/功能受损可能在肿瘤诱导的细胞介导免疫抑制中起关键作用，并且这种抑制与Cy敏感的抑制细胞无关。
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