Kahramanmaras Sutcu Imam University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kahramanmaras.
Gazi University, Faculty of Dentistry, Department Oral and Maxillofacial Radiology, Ankara.
J Craniofac Surg. 2022 Sep 1;33(6):1929-1933. doi: 10.1097/SCS.0000000000008390. Epub 2021 Dec 1.
This study aimed to evaluate the effects of chlorhexidine, metronidazole, and ozone application on the healing of palatal wounds in diabetic rats. A defect in the form of a 4 mm-diameter wound was created on the palatal mucosa of 84 adult female Wistar albino rats, which were randomly divided into 4 groups: control, chlorhexidine, metronidazole, and ozone groups. The animals were euthanized after 3, 6, and 10 days, and wound closure was histologically assessed. On day 3, polymorphonuclear leukocytes were significantly higher in the control group than in the chlorhexidine and ozone groups ( P < 0.05). Fibrosis was higher in the ozone group than in the control and chlorhexidine groups ( P < 0.05). Vascular endothelial growth factor was higher in the metronidazole and ozone groups than in the control group ( P < 0.05). On day 6, the quantity of polymorphonuclear leukocytes was higher in the control, metronidazole, and chlorhexidine groups than in the ozone group ( P < 0.05). Vascular endothelial growth factor was higher in the ozone group than in the control, chlorhexidine, and metronidazole groups ( P < 0.05). On day 10, Vascular endothelial growth factor was higher in the control, chlorhexidine, and metronidazole groups than in the ozone group ( P < 0.05). The authors concluded that the use of chlorhexidine, ozone, and metronidazole pastes resulted in enhanced wound healing, as determined histologically.The authors suggest that ozone supplementation can be an alternative therapy to chlorhexidine in impaired wound healing in diabetes mellitus.
本研究旨在评估洗必泰、甲硝唑和臭氧应用对糖尿病大鼠腭部伤口愈合的影响。在 84 只成年雌性 Wistar 白化大鼠的腭黏膜上形成一个 4 毫米直径的伤口，将它们随机分为 4 组：对照组、洗必泰组、甲硝唑组和臭氧组。在第 3、6 和 10 天处死动物，对伤口愈合情况进行组织学评估。第 3 天，与洗必泰和臭氧组相比，对照组的多形核白细胞明显更高（P<0.05）。臭氧组的纤维化程度高于对照组和洗必泰组（P<0.05）。与对照组相比，甲硝唑组和臭氧组的血管内皮生长因子更高（P<0.05）。第 6 天，与臭氧组相比，对照组、甲硝唑组和洗必泰组的多形核白细胞数量更多（P<0.05）。臭氧组的血管内皮生长因子高于对照组、洗必泰组和甲硝唑组（P<0.05）。第 10 天，与臭氧组相比，对照组、洗必泰组和甲硝唑组的血管内皮生长因子更高（P<0.05）。作者得出结论，洗必泰、臭氧和甲硝唑糊剂的使用可促进伤口愈合，这可通过组织学确定。作者建议，在糖尿病受损的伤口愈合中，臭氧补充剂可以替代洗必泰作为一种治疗方法。
