Mariano Ronaldo Célio, Oliveira Marina Reis, Silva Leopoldo Cosme, Ferreira Sabrina, Garcia Júnior Idelmo Rangel, de Carvalho Silva Amanda
Titular Professor of Department of Clinic and Surgery, Faculty of Dentistry, Federal University of Alfenas, Minas Gerais, Brazil.
PhD student in Diagnostic and Surgery, Faculty of Dentistry of Araraquara, São Paulo State University, Sao Paulo, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 May;119(5):505-13. doi: 10.1016/j.oooo.2014.12.023. Epub 2015 Jan 9.
This study investigated the effect of topical application of 2% chlorhexidine (GCl) and metronidazole (Gme) pastes for the repair of palatal wounds in rats.
A 4-mm diameter wound was created on the palates of 27 rats separated randomly into 3 groups of 9 animals each, according to the treatment received: GNa (Control: natrosol), GCl, and GMe. The animals were euthanized after 3, 6, and 10 days, and wound closure was clinically and histomorphometrically assessed.
Clinical evaluation showed a statistically significant difference in tissue repair with GCl and GMe compared with GNa. In histomorphometric analysis, the highest values in the areas of the epithelium and keratin were observed for GCl and GMe; however, compared with Gna, no statistically significant differences were observed.
GCl and GMe pastes showed promising results with regard to tissue repair from a clinical point of view. Histologically, premature closure of wounds was noted in most specimens on day 6. Although no statistically significant differences were observed among the experimental groups with regard to histometry of the epithelium and keratin, the highest means were observed for GCl.
本研究调查了局部应用2%氯己定（GCl）糊剂和甲硝唑（Gme）糊剂对大鼠腭部伤口修复的影响。
在27只大鼠的腭部制造直径4毫米的伤口，根据接受的治疗将其随机分为3组，每组9只动物：GNa（对照组：羟丙基甲基纤维素）、GCl和GMe。在3天、6天和10天后对动物实施安乐死，并对伤口闭合情况进行临床和组织形态计量学评估。
临床评估显示，与GNa相比，GCl和GMe在组织修复方面存在统计学上的显著差异。在组织形态计量学分析中，GCl和GMe在上皮和角质层面积方面观察到最高值；然而，与GNa相比，未观察到统计学上的显著差异。
从临床角度来看，GCl和GMe糊剂在组织修复方面显示出有前景的结果。组织学上，在第6天大多数标本中观察到伤口过早闭合。尽管在实验组之间关于上皮和角质层的组织测量学未观察到统计学上的显著差异，但GCl观察到最高均值。
