Department of Ophthalmology, Ruijin Hospital, Shanghai Jiaotong University of Medicine, Shanghai, China.
Department of Ophthalmology, Wuxi Branch of Ruijin Hospital, Shanghai Jiaotong University of Medicine, Shanghai, China.
BMC Ophthalmol. 2021 Dec 2;21(1):415. doi: 10.1186/s12886-021-02154-4.
To establish normal parameters of macular and optic disc vasculature by optical coherence tomography angiography (OCTA) in healthy preschool children aged 4-6 years old in China. OCTA reflects retinal metabolism and development in children at these ages and could be used clinically and in future studies to aid diagnosis and prediction of retinal abnormalities and developmental stagnation.
In this cross-sectional study, we measured foveal, parafoveal, and perifoveal vessel density in the superficial capillary plexus (SCP); the deep capillary plexus (DCP), the foveal avascular zone (FAZ), and the radial capillary peripapillary (RPC) in the optic disc using investigational spectral-domain OCTA. The magnification effect of the FAZ area and microvasculature measurements was corrected by Littman and the modified Bennett formula.
A total of 242 eyes (116 males and 126 females, 5.31 ± 0.73 years) were recruited for the analysis. The mean macular vessel density was 48.10 ± 2.92% and 48.74 ± 6.51% in the SCP and the DCP, respectively. The RPC vessel density was 47.17 ± 2.52%, 47.99 ± 4.48%, and 48.41 ± 3.07% in the whole image, inside disc, and peripapillary, respectively; and the mean FAZ area was 0.28 ± 0.11 mm. A significant difference between male and female participants was found in the retinal vasculature (DCP, SCP, and RPC). None of these parameters were significantly different in age (P > 0.05), except that DCP slightly increased with aging. The right and left eyes had good consistency in the parameters of the macula and optic disc.
Our study establishes the macular and optic disc OCTA reference values in 4- to 6-year-old healthy preschool children. They may be used in longitudinal OCTA studies and clinical applications.
通过光学相干断层扫描血管造影术（OCTA）在中国 4-6 岁健康学龄前儿童中建立黄斑和视盘血管的正常参数。OCTA 反映了这些年龄儿童的视网膜代谢和发育情况，可在临床上和未来的研究中用于辅助诊断和预测视网膜异常和发育停滞。
在这项横断面研究中，我们使用研究性频域 OCTA 测量了浅层毛细血管丛（SCP）中的中心凹、旁中心凹和周边区血管密度；深层毛细血管丛（DCP）中的中心凹无血管区（FAZ）和视盘放射状毛细血管周边（RPC）。FAZ 面积和微血管测量的放大效应通过 Littman 和改良 Bennett 公式进行校正。
共纳入 242 只眼（男性 116 只，女性 126 只，平均年龄 5.31±0.73 岁）进行分析。SCP 和 DCP 的平均黄斑血管密度分别为 48.10±2.92%和 48.74±6.51%。RPC 血管密度分别为全像、视盘内和视盘旁的 47.17±2.52%、47.99±4.48%和 48.41±3.07%；平均 FAZ 面积为 0.28±0.11mm。男性和女性参与者之间在视网膜血管（DCP、SCP 和 RPC）方面存在显著差异。除 DCP 随年龄略有增加外，这些参数在年龄上无显著差异（P>0.05）。右眼和左眼在黄斑和视盘参数方面具有良好的一致性。
本研究建立了 4-6 岁健康学龄前儿童黄斑和视盘 OCTA 的参考值。它们可用于纵向 OCTA 研究和临床应用。
