Division of Allergy, Department of Medical Subspecialties, Medical Support Center for Japan Environment and Children's Study (JECS), Allergy Center, National Center for Child Health and Development, 2-10-1, Okura, Setagayaku, Tokyo, 157-8535, Japan.
Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, Japan.
BMC Pediatr. 2021 Dec 2;21(1):539. doi: 10.1186/s12887-021-03005-3.
The study aim was to obtain epidemiological data on vitamin D levels for the pediatric population in Japan. We assessed the prevalence of vitamin D deficiency and insufficiency in 2-year-old Japanese children using data from a large ongoing birth cohort study.
Data for analysis was obtained from the Japan Environment and Children's Study (JECS) and a Sub-Cohort Study (SCS) of JECS. We evaluated the children's serum 25(OH) D levels by 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles, and the rates of vitamin D deficiency or insufficiency. We also presented a weighted prevalence rate for vitamin D deficiency or insufficiency among all children in JECS.
After excluding children with missing 25(OH)D2 or 25(OH)D3 data, we analyzed 4655 remaining children, of whom 24.7% (95% CI, 23.5-26.0%) had vitamin D deficiency (< 20 ng/mL), and 51.3% (95% CI, 49.8-52.7%) were at risk of vitamin D insufficiency (20-30 ng/mL). The estimated prevalence of vitamin D deficiency and insufficiency among all children in JECS were 25.4% (95% CI, 24.1-26.7%) and 50.9% (95% CI, 49.4-52.4%). Vitamin D deficiency was found in 22.9% of boys and 26.5% of girls. Median serum 25(OH) D concentrations were lower among participants measured during winter and spring than among those measured in summer and autumn. The highest rate of vitamin D deficiency was observed in Hokkaido, the northernmost prefecture of Japan.
We analyzed data on serum 25(OH) D levels from a birth cohort study and found that vitamin D deficiency and insufficiency are very common among 2-year-old Japanese children. Sex, season, and latitude affect serum 25(OH) D concentrations.
本研究旨在获取日本儿科人群维生素 D 水平的流行病学数据。我们利用一项大型正在进行的出生队列研究的数据，评估了 2 岁日本儿童维生素 D 缺乏和不足的流行情况。
分析数据来自日本环境与儿童研究（JECS）及其子队列研究（SCS）。我们通过第 5、10、25、50、75、90 和 95 百分位数评估了儿童血清 25(OH)D 水平，以及维生素 D 缺乏或不足的发生率。我们还呈现了 JECS 中所有儿童维生素 D 缺乏或不足的加权患病率。
排除了 25(OH)D2 或 25(OH)D3 数据缺失的儿童后，我们分析了 4655 名剩余儿童，其中 24.7%（95%CI，23.5-26.0%）存在维生素 D 缺乏症（＜20ng/mL），51.3%（95%CI，49.8-52.7%）存在维生素 D 不足的风险（20-30ng/mL）。JECS 中所有儿童维生素 D 缺乏和不足的估计患病率分别为 25.4%（95%CI，24.1-26.7%）和 50.9%（95%CI，49.4-52.4%）。男孩和女孩的维生素 D 缺乏率分别为 22.9%和 26.5%。冬季和春季测量的参与者血清 25(OH)D 浓度中位数低于夏季和秋季测量的参与者。日本最北部的北海道维生素 D 缺乏率最高。
我们分析了来自出生队列研究的血清 25(OH)D 水平数据，发现 2 岁日本儿童中维生素 D 缺乏和不足非常普遍。性别、季节和纬度会影响血清 25(OH)D 浓度。
