Bendich A, Gabriel E, Machlin L J
J Nutr. 1986 Apr;116(4):675-81. doi: 10.1093/jn/116.4.675.
Supplementation of diets with vitamin E has been shown to enhance immune responses in numerous animal models. However, these experiments have not investigated the dietary requirement of vitamin E for optimal T- and B-lymphocyte mitogen responses and compared this directly with the requirement for growth, maintenance of spleen-body weight ratios, platelet count as well as prevention of myopathy and red blood cell lysis. We have found that male weanling rats maintain normal rate of growth and spleen-body weight ratio when fed purified diets containing 7.5 mg/kg vitamin E. A level of 15 mg/kg was adequate to prevent myopathy, and 50 mg/kg was necessary for the prevention of red blood cell hemolysis. The dietary requirement for optimum T- and B-lymphocyte responses to mitogens was greater than 50 mg/kg and was significantly correlated with plasma vitamin E levels over a range of 0.04-18 micrograms/ml. Thus, the requirement for this index of immune system activity was higher than for the other functional parameters of vitamin E adequacy measured. Therefore, the immune system responds to changes in dietary vitamin E well before there are signs of frank vitamin deficiency.
在众多动物模型中，已证实饮食中补充维生素E可增强免疫反应。然而，这些实验并未研究维生素E对最佳T淋巴细胞和B淋巴细胞有丝分裂原反应的饮食需求，也未将其与生长需求、脾脏与体重比的维持、血小板计数以及预防肌病和红细胞溶解的需求直接进行比较。我们发现，雄性断奶大鼠在喂食含7.5毫克/千克维生素E的纯化饮食时，能维持正常的生长速度和脾脏与体重比。15毫克/千克的水平足以预防肌病，而预防红细胞溶血则需要50毫克/千克。对有丝分裂原产生最佳T淋巴细胞和B淋巴细胞反应的饮食需求大于50毫克/千克，并且在0.04 - 18微克/毫升的范围内与血浆维生素E水平显著相关。因此，对免疫系统活动这一指标的需求高于对所测量的维生素E充足性的其他功能参数的需求。所以，在出现明显维生素缺乏迹象之前，免疫系统就能对饮食中维生素E的变化做出反应。
