Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Clin Nutr ESPEN. 2021 Dec;46:106-114. doi: 10.1016/j.clnesp.2021.09.013. Epub 2021 Sep 29.
Cardiovascular diseases (CVDs) are the number one cause of mortality worldwide. Apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), and ApoB/ApoA1 ratio are considered as predictors of CVD alongside with lipid profile. Evidence suggest that nutrients with antioxidant properties, especially vitamin E, are essential for a healthy cardiovascular system. The aim of present meta-analysis was to determine the effect alpha-tocopherol on ApoA1 and ApoB levels.
PubMed-Medline and SCOPUS databases and Google Scholar were searched up to July 2021. Random-effects model was employed to perform meta-analysis. In order to find heterogeneity sources, subgroup analysis was performed. Trim and fill analysis was performed in case of presence of publication bias. Quality assessment was performed using Cochrane Collaboration's tool.
Seven eligible studies, involving 1284 individuals were included. Mean age of participants ranged between 25.4 and 59 years. There was no significant effect of vitamin E supplementation on Apo A1 (SMD = 0.22 IU/d; 95% CI: -0.38, 0.28; P = 0.481) and Apo B levels (SMD = -0.62 IU/d; 95% CI: -1.94, 0.70; P = 0.360).
No remarkable effect of vitamin E supplementation was observed on ApoA1 and ApoB levels in adults. Additional studies investigating the influence of vitamin E on apolipoproteins as primary outcome with larger sample size are suggested.
心血管疾病（CVDs）是全球首要死因。载脂蛋白 B（ApoB）、载脂蛋白 A1（ApoA1）和 ApoB/ApoA1 比值与血脂谱一起被认为是 CVD 的预测指标。有证据表明，具有抗氧化特性的营养素，尤其是维生素 E，对心血管系统的健康是必不可少的。本荟萃分析的目的是确定α-生育酚对 ApoA1 和 ApoB 水平的影响。
检索了 PubMed-Medline 和 SCOPUS 数据库以及 Google Scholar，检索截至 2021 年 7 月。采用随机效应模型进行荟萃分析。为了寻找异质性来源，进行了亚组分析。如果存在发表偏倚，则进行 Trim and Fill 分析。使用 Cochrane 协作工具进行质量评估。
纳入了 7 项符合条件的研究，涉及 1284 名个体。参与者的平均年龄在 25.4 至 59 岁之间。维生素 E 补充对 ApoA1（SMD = 0.22 IU/d；95%CI：-0.38，0.28；P = 0.481）和 ApoB 水平（SMD = -0.62 IU/d；95%CI：-1.94，0.70；P = 0.360）没有显著影响。
在成年人中，维生素 E 补充对 ApoA1 和 ApoB 水平没有显著影响。建议进行更多研究，以维生素 E 作为主要结局指标，评估其对载脂蛋白的影响，且样本量要更大。
