Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
Nutrients. 2023 Jul 25;15(15):3301. doi: 10.3390/nu15153301.
The relationship between vitamin E intake or circulating α-tocopherol and various health outcomes is still debatable and uncertain. We conducted an umbrella review to identify the relationships between vitamin E intake or circulating tocopherol and health outcomes by merging and recalculating earlier meta-analyses. The connections that were found to be statistically significant were then classified into different evidence levels based on values, between-study heterogeneity, prediction intervals, and small study effects. We finally included 32 eligible meta-analyses with four vitamin E sources and 64 unique health outcomes. Only the association between circulating α-tocopherol and wheeze or asthma in children was substantiated by consistent evidence. Suggestive evidence was suggested for seven results on endothelial function (supplemental vitamin E): serum C-reactive protein (CRP) concentrations (supplemental vitamin E), cervical cancer (dietary vitamin E), esophageal cancer (dietary vitamin E), cervical intraepithelial neoplasia (CIN, dietary vitamin E), pancreatic cancer (total vitamin E intake), and colorectal cancer (circulating α-tocopherol levels); all of these showed a protective effect consistent with the vitamin E source. In conclusion, our work has indicated that vitamin E is protective for several particular health outcomes. Further prospective studies are required when other factors that may contribute to bias are considered.
维生素 E 摄入或循环 α-生育酚与各种健康结果之间的关系仍存在争议和不确定。我们通过合并和重新计算以前的荟萃分析来进行伞式审查，以确定维生素 E 摄入或循环生育酚与健康结果之间的关系。然后根据 值、研究间异质性、预测区间和小样本效应，将具有统计学意义的关联分类为不同的证据水平。我们最终纳入了 32 项符合条件的荟萃分析，涉及 4 种维生素 E 来源和 64 种独特的健康结果。只有循环 α-生育酚与儿童喘息或哮喘之间的关联得到了一致证据的支持。对内皮功能（补充维生素 E）的七个结果提出了提示性证据：血清 C 反应蛋白（CRP）浓度（补充维生素 E）、宫颈癌（膳食维生素 E）、食管癌（膳食维生素 E）、宫颈上皮内瘤变（CIN，膳食维生素 E）、胰腺癌（总维生素 E 摄入量）和结直肠癌（循环 α-生育酚水平）；所有这些结果都显示出与维生素 E 来源一致的保护作用。总之，我们的工作表明，维生素 E 对几种特定的健康结果具有保护作用。当考虑到可能导致偏倚的其他因素时，需要进行进一步的前瞻性研究。
