Ruder Bošković Institute, Materials Physics Division, Bijeniška cesta 54, 10000 Zagreb, Croatia; Lund Institute for advanced Neutron and X-ray Science (LINXS), Lund University, IDEON Building, Delta 5, Scheelevägen 19, 223 70 Lund, Sweden.
Department of Engineering and Architecture, Trieste University, via Valerio 6, I-34127 Trieste, Italy.
Mater Sci Eng C Mater Biol Appl. 2021 Dec;131:112480. doi: 10.1016/j.msec.2021.112480. Epub 2021 Oct 14.
The open border between non-living and living matter, suggested by increasingly emerging fields of nanoscience interfaced to biological systems, requires a detailed knowledge of nanomaterials properties. An account of the wide spectrum of phenomena, belonging to physical chemistry of interfaces, materials science, solid state physics at the nanoscale and bioelectrochemistry, thus is acquainted for a comprehensive application of carbon nanotubes interphased with neuron cells. This review points out a number of conceptual tools to further address the ongoing advances in coupling neuronal networks with (carbon) nanotube meshworks, and to deepen the basic issues that govern a biological cell or tissue interacting with a nanomaterial. Emphasis is given here to the properties and roles of carbon nanotube systems at relevant spatiotemporal scales of individual molecules, junctions and molecular layers, as well as to the point of view of a condensed matter or materials scientist. Carbon nanotube interactions with blood-brain barrier, drug delivery, biocompatibility and functionalization issues are also regarded.
非生命和生命物质之间的开放边界，由与生物系统接口的纳米科学领域日益凸显，这需要对纳米材料性能有详细的了解。因此，为了全面应用与神经元细胞成相的碳纳米管，需要了解属于界面物理化学、材料科学、纳米尺度固态物理学和生物电化学的广泛现象范围。本综述指出了一些概念工具，以进一步解决神经元网络与（碳）纳米管网格结合的持续进展，并深化控制与纳米材料相互作用的生物细胞或组织的基本问题。这里的重点是在单个分子、连接和分子层的相关时空尺度上的碳纳米管系统的性质和作用，以及凝聚态或材料科学家的观点。还考虑了碳纳米管与血脑屏障、药物输送、生物相容性和功能化问题的相互作用。
