Biçer Gamze Yıldırım, Zor Kürşad Ramazan, Biçer Kadir Eren, Küçük Erkut, Küçük Esin Benli
Niğde Ömer Halisdemir University School of Medicine Department of Ophthalmology, Niğde, MD, Turkey.
Niğde Ömer Halisdemir Education and Research Hospital Department of Orthopedics and Traumatology, Niğde, MD, Turkey.
Eye (Lond). 2022 Dec;36(12):2318-2322. doi: 10.1038/s41433-021-01864-9. Epub 2021 Dec 2.
In this study, the effects of long-term pregabalin use on the choroid and retinal nerve fiber layer were investigated in the fibromyalgia disease.
The patient group consisted of 41 fibromyalgia patients using pregabalin. The control group consisted of 41 newly diagnosed fibromyalgia patients who had not received any treatment yet. Choroidal and retinal nerve fiber layer thickness measurements were performed with Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, USA) 30 minutes after pupil dilation with 1% tropicamide.
There was no difference in subfoveal choroidal thickness, nasal choroidal thickness and temporal choroidal thickness between the patient and control groups (p > 0.05). Increasing the duration of drug use within the patient group was found to thin the retinal nerve fiber layer (p < 0.05).
We found that pregabalin had no effect on the choroid, while it had a thinning effect for retinal nerve fiber layer. It is recommended not to be preferred pregabalin in fibromyalgia patients with retinal nerve fiber layer damage such as diabetic retinopathy and glaucoma. Patients treated with pregabalin should have regular control in the ophthalmology clinic.
在本研究中，调查了长期使用普瑞巴林对纤维肌痛疾病脉络膜和视网膜神经纤维层的影响。
患者组由41名使用普瑞巴林的纤维肌痛患者组成。对照组由41名尚未接受任何治疗的新诊断纤维肌痛患者组成。在使用1%托吡卡胺散瞳30分钟后，使用Cirrus HD-OCT（卡尔·蔡司医疗技术公司，美国加利福尼亚州都柏林）进行脉络膜和视网膜神经纤维层厚度测量。
患者组和对照组之间的黄斑中心凹下脉络膜厚度、鼻侧脉络膜厚度和颞侧脉络膜厚度没有差异（p＞0.05）。发现在患者组内增加用药时间会使视网膜神经纤维层变薄（p＜0.05）。
我们发现普瑞巴林对脉络膜没有影响，而对视网膜神经纤维层有变薄作用。建议在患有糖尿病性视网膜病变和青光眼等视网膜神经纤维层损伤的纤维肌痛患者中不要首选普瑞巴林。接受普瑞巴林治疗的患者应在眼科诊所定期检查。
