Abdellatif Mona K, Fouad Mohamed M
1 Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2 Department of Neuropsychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eur J Ophthalmol. 2018 Nov;28(6):714-721. doi: 10.1177/1120672117750054. Epub 2018 Mar 23.
: To investigate the factors in migraine that have the highest significance on retinal and choroidal layers' thickness.
: Ninety patients with migraine and 40 age-matched healthy participants were enrolled in this observational, cross-sectional study. After full ophthalmological examination, spectral domain-optical coherence tomography was done for all patients measuring the thickness of ganglion cell layer and retinal nerve fiber layer. Enhanced depth imaging technique was used to measure the choroidal thickness.
: There was significant thinning in the superior and inferior ganglion cell layers, all retinal nerve fiber layer quadrants, and all choroidal quadrants (except for the central subfield) in migraineurs compared to controls. The duration of migraine was significantly correlated with ganglion cell layer, retinal nerve fiber layer, and all choroidal quadrants, while the severity of migraine was significantly correlated with ganglion cell layer and retinal nerve fiber layer only. Multiregression analysis showed that the duration of migraine is the most important determinant factor of the superior retinal nerve fiber layer quadrant (β = -0.375, p = 0.001) and in all the choroidal quadrants (β = -0.531, -0.692, -0.503, -0.461, -0.564, respectively, p < 0.001), while severity is the most important determinant factor of inferior, nasal, and temporal retinal nerve fiber layer quadrants (β = -0.256, -0.335, -0.308; p = 0.036, 0.005, 0.009, respectively) and the inferior ganglion cell layer hemisphere (β = -0.377 and p = 0.001).
: Ganglion cell layer, retinal nerve fiber layer, and choroidal thickness are significantly thinner in patients with migraine. The severity of migraine has more significant influence in the thinning of ganglion cell layer and retinal nerve fiber layer, while the duration of the disease affected the choroidal thickness more.
研究偏头痛中对视网膜和脉络膜层厚度影响最为显著的因素。
本观察性横断面研究纳入了90例偏头痛患者和40例年龄匹配的健康参与者。在进行全面的眼科检查后，对所有患者进行了光谱域光学相干断层扫描，测量神经节细胞层和视网膜神经纤维层的厚度。采用增强深度成像技术测量脉络膜厚度。
与对照组相比，偏头痛患者的上、下神经节细胞层、所有视网膜神经纤维层象限以及所有脉络膜象限（中央子区域除外）均有明显变薄。偏头痛的病程与神经节细胞层、视网膜神经纤维层以及所有脉络膜象限显著相关，而偏头痛的严重程度仅与神经节细胞层和视网膜神经纤维层显著相关。多元回归分析显示，偏头痛病程是视网膜神经纤维层上象限（β = -0.375，p = 0.001）和所有脉络膜象限（β分别为 -0.531、-0.692、-0.503、-0.461、-0.564，p < 0.001）最重要的决定因素，而严重程度是视网膜神经纤维层下、鼻侧和颞侧象限（β = -0.256、-0.335、-0.308；p分别为0.036、0.005、0.009）以及下神经节细胞层半球（β = -0.377，p = 0.001）最重要的决定因素。
偏头痛患者的神经节细胞层、视网膜神经纤维层和脉络膜厚度明显变薄。偏头痛的严重程度对神经节细胞层和视网膜神经纤维层变薄的影响更为显著，而病程对脉络膜厚度的影响更大。
