Dai Chengjun, Wang Chaoban, Xia Fangqin, Liu Zishuo, Mo Yiqi, Shan Xiaoou, Zhou Yonghai
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Front Pediatr. 2021 Nov 10;9:560720. doi: 10.3389/fped.2021.560720. eCollection 2021.
Hyperuricemia is defined when the plasma uric acid concentration is above 416 μmol/L (7 mg/dl) in male adults, or 357 μmol/L (6 mg/dl) in female adults. However, there are no explicit criteria yet for children. It is necessary to set up reference intervals for the uric acid level in different age groups among children. A total of 5,439 individuals (3,258 males, 2,181 females) were included in the final statistical analysis. Reference values of all age groups were determined by statistical descriptions. Multiple linear regression analysis was applied to determine the relationship between uric acid level, BMI, and age. The level of uric acid increased with age. Gender differences in uric acid level occurred after the onset of puberty. Additionally, linear regression revealed a positive correlation between the uric acid level and BMI. The reference range of the uric acid level in children is inconsistent with the previous viewpoint. Body mass index plays an important role in uric acid metabolism.
成年男性血浆尿酸浓度高于416μmol/L（7mg/dl），成年女性高于357μmol/L（6mg/dl）时，定义为高尿酸血症。然而，目前尚无针对儿童的明确标准。有必要建立不同年龄组儿童尿酸水平的参考区间。最终纳入统计分析的共有5439人（男性3258人，女性2181人）。通过统计描述确定所有年龄组的参考值。应用多元线性回归分析来确定尿酸水平、体重指数（BMI）和年龄之间的关系。尿酸水平随年龄增长而升高。尿酸水平的性别差异在青春期开始后出现。此外，线性回归显示尿酸水平与BMI呈正相关。儿童尿酸水平的参考范围与先前观点不一致。体重指数在尿酸代谢中起重要作用。
