Department of Biomedical, Metabolic and Neural Sciences, University of Modena & Reggio Emilia, Modena, Italy.
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Front Public Health. 2021 Nov 11;9:756566. doi: 10.3389/fpubh.2021.756566. eCollection 2021.
Solar UltraViolet Radiation (UVR) is considered the most relevant occupational carcinogenic exposure in terms of the number of workers exposed (i.e., outdoor workers) and UVR-induced skin cancers are among the most frequent types of occupational cancers worldwide. This review aims to collect and evaluate all the available preventive interventions conducted on outdoor workers to reduce their solar UVR related risk, with the final purpose of reducing the burden of occupational skin cancers for outdoor workers. We will search the following databases for peer-reviewed original research published: MEDLINE (through PubMed), Scopus, and EMBASE. We will include only interventional studies, both randomized and non-randomized, with an adequate comparison group, therefore excluding cross-sectional studies, as well as case-reports/series, reviews, and letters/comments. The systematic review will adhere to the "Preferred Reporting Items for Systematic reviews and Meta-Analyses" (PRISMA) guidelines for reporting systematic reviews. After the literature search, studies to be included will be independently reviewed by two Authors, first based on title and abstract, then based on the full text, according to the inclusion criteria. Conflicts will be solved by a third Author. Two authors will independently extract the required data from included studies and perform quality assessment according to the relevant domain for Risk of Bias assessment proposed by the Cochrane collaboration group. In case of sufficient homogeneity of interventions and outcomes evaluated, results from subgroups of studies will be pooled together in a meta-analysis. Following the principles for the evaluation of interventions for cancer prevention established by the International Agency for Research on Cancer, this systematic review will investigate the effectiveness of the interventions, and consequently it will provide reliable indications for the actual reduction of skin cancer incidence in outdoor workers.
太阳紫外线辐射 (UVR) 被认为是与暴露人数（即户外工作者）相关的最相关的职业致癌因素，而 UVR 诱发的皮肤癌是全球最常见的职业癌之一。本综述旨在收集和评估所有针对户外工作者进行的预防干预措施，以降低他们与太阳 UVR 相关的风险，最终目的是降低户外工作者职业性皮肤癌的负担。
MEDLINE（通过 PubMed）、Scopus 和 EMBASE。我们将只纳入干预性研究，包括随机和非随机研究，并设有适当的对照组，因此排除了横断面研究，以及病例报告/系列、综述和信件/评论。系统评价将遵循“系统评价和荟萃分析的首选报告项目”（PRISMA）报告系统评价的指南。文献搜索后，将由两位作者独立根据标题和摘要、然后根据全文对符合纳入标准的研究进行审查。如有冲突，将由第三位作者解决。两位作者将独立从纳入的研究中提取所需数据，并根据 Cochrane 协作组提出的风险偏倚评估相关领域进行质量评估。如果干预措施和评估结果具有足够的同质性，将对研究的亚组进行汇总分析。
根据国际癌症研究机构（IARC）制定的癌症预防干预措施评估原则，本系统评价将调查干预措施的有效性，并为户外工作者皮肤癌发病率的实际降低提供可靠的依据。
