Miarka Lauritz, Valiente Manuel
Brain Metastasis Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Neurooncol Adv. 2021 Nov 27;3(Suppl 5):v144-v156. doi: 10.1093/noajnl/vdab115. eCollection 2021 Nov.
Modeling of metastatic disease in animal models is a critical resource to study the complexity of this multi-step process in a relevant system. Available models of metastatic disease to the brain are still far from ideal but they allow to address specific aspects of the biology or mimic clinically relevant scenarios. We not only review experimental models and their potential improvements but also discuss specific answers that could be obtained from them on unsolved aspects of clinical management.
在动物模型中模拟转移性疾病是在相关系统中研究这一多步骤过程复杂性的关键资源。现有的脑转移性疾病模型仍远非理想，但它们能够解决生物学的特定方面问题或模拟临床相关情况。我们不仅回顾了实验模型及其潜在的改进，还讨论了可以从这些模型中获得的关于临床管理未解决方面的具体答案。
