Department of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Graduate School of Peking Union Medical College, Beijing, China.
J Med Virol. 2022 Jun;94(6):2787-2795. doi: 10.1002/jmv.27498. Epub 2021 Dec 15.
The prevalence of human papillomavirus (HPV) infection and HPV genotypes varies in different regions. However, there is little data on HPV prevalence and genotyping in Guangxi Province, South China. This study conducted a 10-year survey in a health center, to estimate the prevalence characteristics of HPV genotypes.
By using polymerase chain reaction (PCR) amplification and nucleic acid molecular hybridization, the HPV genotypes were detected from 77,756 females who were patients of the Department of Obstetrics and Gynecology and those who visited the Health Management Center for a physical examination between August 2011 and November 2020. The prevalence, genotypes, age-related HPV infections, as well as chronological change of HPV prevalence, and the HPV genotype distribution were analyzed.
The overall prevalence of HPV infection was 21.14% (16,439/77,756). The HPV infection rate differed significantly between the patients of the Department of Obstetrics and Gynecology and the women who underwent a physical examination (22.98% vs. 9.88%, p < 0.05). The prevalence rates of high-risk HPV, low-risk HPV, mixed HPV (mixed high-risk, and low-risk HPV infection), and multiple HPV infections were 18.96% (14,739/77,756), 4.09% (3178/77,756), 1.90% (1478/77,756), and 4.94% (3838/77,756), respectively. The most prevalent genotypes were HPV 52, 16, and 58. The age-associated HPV prevalence showed bimodal curves, with the first peak at <25 years and the second peak at >56 years.
This study provides baseline data on the HPV prevalence in the general female population of Nanning, Guangxi Province. Women <25 and >56 years old faced the greatest threat of HPV infection, and HPV 52, 16, and 58 were the most common genotypes.
人乳头瘤病毒（HPV）感染和 HPV 基因型在不同地区的流行情况存在差异。然而，关于中国南方广西省 HPV 的流行情况和基因分型数据较少。本研究对某卫生中心进行了为期 10 年的调查，以评估 HPV 基因型的流行特征。
采用聚合酶链反应（PCR）扩增和核酸分子杂交技术，对 2011 年 8 月至 2020 年 11 月期间在妇产科就诊的患者和健康管理中心体检的女性 77756 例进行 HPV 基因型检测。分析 HPV 感染的流行率、基因型、年龄相关感染情况，以及 HPV 流行率的时间变化和 HPV 基因型分布。
HPV 总感染率为 21.14%（16439/77756）。妇产科患者和体检女性的 HPV 感染率差异有统计学意义（22.98% vs. 9.88%，p<0.05）。高危型 HPV、低危型 HPV、混合 HPV（高危型和低危型混合感染）和多重 HPV 感染的流行率分别为 18.96%（14739/77756）、4.09%（3178/77756）、1.90%（1478/77756）和 4.94%（3838/77756）。最常见的 HPV 基因型为 HPV 52、16 和 58。年龄相关 HPV 流行率呈双峰曲线，第一个高峰在<25 岁，第二个高峰在>56 岁。
本研究为广西南宁普通女性人群 HPV 流行率提供了基线数据。<25 岁和>56 岁的女性面临最大的 HPV 感染威胁，HPV 52、16 和 58 是最常见的基因型。
