Lin Kun, Hong Qiyang, Fu Ya, Tu Haijian, Lin Hua, Huang Jiexiang, Hu Yajing, Huang Minjun, Chen Mingqiao
Prenatal Diagnosis Center, The Affiliated Hospital of Putian University, Putian University, Putian, China.
Department of Laboratory Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Front Microbiol. 2024 Jun 19;15:1418218. doi: 10.3389/fmicb.2024.1418218. eCollection 2024.
To comprehensively analyze the epidemiological features of human papillomavirus (HPV) and HPV-related cervical diseases in females aged 35-64 years.
A total of 149,559 samples of exfoliated cervical cells screened for HPV and related cervical lesions from January 2018 to December 2023 were enrolled. The prevalence of 15 high-risk and 6 low-risk HPV genotypes were detected, and the cervical cytology were analyzed. The impact of single and multiple HPV infections was characterized, and the effect of age was studied.
The cervix cytology was normal in 86.60% of the females, while 7.13% of the females were diagnosed with cervix inflammation, 0.60% with ASC-US, 0.22% with ASC-H, 0.72% with LSIL, 0.49% with HSIL, 0.03% with ICC. The highest median age was observed in ASC-H group with 54 years old. Females with primary school education or lower have the highest positive rates. The overall HPV prevalence was 8.60%. The relatively prevalent HPV types were HPV52, 58, 16, 39, 51. HPV16, HPV18, HPV58, HPV33 and HPV52 were the top5 predominant types in ICC patients. 17.41% females suffered from multiple HPV infection with the most frequently co-infection subtypes being HPV52, HPV58 and HPV16. The prevalence of all HPV subtypes increased with age. Multiple HPV infections accounted for a larger proportion in those aged above 55 years. The peak HPV16 prevalence was observed in ICC group in cases aged 45-49 and 55-59. The peak HPV33 prevalence was observed in younger individuals aged 40-44 who developed ICC.
More action should be taken against HPV33 infection.
全面分析35 - 64岁女性人乳头瘤病毒（HPV）及HPV相关宫颈疾病的流行病学特征。
纳入2018年1月至2023年12月期间共149,559例筛查HPV及相关宫颈病变的宫颈脱落细胞样本。检测15种高危和6种低危HPV基因型的流行情况，并分析宫颈细胞学。对单一和多重HPV感染的影响进行了特征描述，并研究了年龄的影响。
86.60%的女性宫颈细胞学正常，7.13%的女性被诊断为宫颈炎症，0.60%为意义不明确的非典型鳞状细胞（ASC-US），0.22%为不典型鳞状细胞不排除高度病变（ASC-H），0.72%为低度鳞状上皮内病变（LSIL），0.49%为高度鳞状上皮内病变（HSIL），0.03%为浸润性宫颈癌（ICC）。ASC-H组的中位年龄最高，为54岁。小学及以下文化程度的女性阳性率最高。HPV总体流行率为8.60%。相对常见的HPV类型为HPV52、58、16、39、51。HPV16、HPV18、HPV58、HPV33和HPV52是ICC患者中排名前5的主要类型。17.41%的女性患有多重HPV感染，最常见的共感染亚型为HPV52、HPV58和HPV16。所有HPV亚型的流行率均随年龄增长而增加。55岁以上人群中多重HPV感染占比更大。在45 - 49岁和55 - 59岁的ICC病例中，HPV16流行率出现峰值。在40 - 44岁患ICC的较年轻个体中，HPV33流行率出现峰值。
应针对HPV33感染采取更多行动。
