奥美拉唑对人肝脏细胞色素P - 450的抑制作用。
Inhibition of human liver cytochrome P-450 by omeprazole.
作者信息
Jensen J C, Gugler R
出版信息
Br J Clin Pharmacol. 1986 Mar;21(3):328-30. doi: 10.1111/j.1365-2125.1986.tb05199.x.
Abstract
The effects of omeprazole on cytochrome P-450 mediated 7-ethoxycoumarin deethylation were studied in human liver microsomes. Omeprazole inhibited both the high and low affinity components of deethylation, with an estimated Ki of 0.03 mM for the high affinity component. The results are further evidence that the previously reported prolongation of the half-life of diazepam by omeprazole in vivo is due to inhibition of cytochrome P-450 monooxygenases.
摘要
在人肝微粒体中研究了奥美拉唑对细胞色素P-450介导的7-乙氧基香豆素脱乙基作用的影响。奥美拉唑抑制了脱乙基作用的高亲和力和低亲和力成分，高亲和力成分的估计抑制常数（Ki）为0.03 mM。这些结果进一步证明，先前报道的奥美拉唑在体内延长地西泮半衰期是由于抑制细胞色素P-450单加氧酶所致。
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