Mach P S, Brouilhet H, Amor B
Clin Exp Immunol. 1986 Feb;63(2):414-8.
The effect of D-Penicillamine (DP) on the in vitro production of anti-DNA antibodies by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE) and from healthy individuals was studied. Anti-DNA antibodies were measured in culture supernatants using a sensitive microenzyme-linked immunoassay technique. The results of this investigation suggest that DP can act as an immunomodulator capable of potentiating or initiating anti-DNA antibodies synthesis as well as suppressing it. Although PBMC from both SLE patients and controls were responsive to this thiol compound, our results indicate that PBMC from patients with SLE were more susceptible to the enhancing effect of DP than did PBMC from controls. The cellular mechanism by which this drug can modulate anti-DNA antibodies production is discussed.
研究了D-青霉胺（DP）对系统性红斑狼疮（SLE）患者和健康个体外周血单个核细胞（PBMC）体外产生抗DNA抗体的影响。使用灵敏的微酶联免疫测定技术检测培养上清液中的抗DNA抗体。本研究结果表明，DP可作为一种免疫调节剂，既能增强或启动抗DNA抗体的合成，也能抑制其合成。虽然SLE患者和对照组的PBMC对这种硫醇化合物均有反应，但我们的结果表明，SLE患者的PBMC比对照组的PBMC对DP的增强作用更敏感。本文讨论了该药物调节抗DNA抗体产生的细胞机制。
