Massof R W, Johnson M A, Sunness J S, Perry C, Finkelstein D
Doc Ophthalmol. 1986 Mar 31;62(3):231-45. doi: 10.1007/BF00212649.
Electroretinograms (ERGs) were recorded as a function of flicker frequency from 5 to 50 Hz for 14 retinitis pigmentosa (RP) patients, 12 normal subjects and 1 rod monochromat. Data were analyzed by measuring the angular position of the response maximum, i.e. the phase, as a function of pulse-train frequency. Flicker ERGs obtained from the RP patients showed non-linear, frequency-dependent phase shifts when compared to the normal data. These phase shifts were simulated in a normal observer by attenuating the stimulus luminance by 1 log unit. However, the shape of the waveforms recorded from the normal differed markedly from those recorded from the RP patients. The differences, but not the ratios of the times-to-peak of the positive and negative ERG wavelets were longer in the RP patients than in the normal. These data suggest that the temporal anomalies in the RP flicker ERG are most likely due to changes in the amplitudes and time constants of the ERG components, and not simply to a reduced quantum catch or photoreceptor loss.
对14例视网膜色素变性（RP）患者、12名正常受试者和1名视杆单色视者记录了闪烁频率从5至50Hz时的视网膜电图（ERG）。通过测量反应最大值的角位置（即相位）作为脉冲序列频率的函数来分析数据。与正常数据相比，RP患者的闪烁ERG显示出非线性、频率依赖性的相移。通过将刺激亮度衰减1个对数单位，在正常观察者中模拟了这些相移。然而，正常受试者记录的波形形状与RP患者记录的波形形状明显不同。RP患者中，ERG正负极小波的峰时差异而非峰时比值比正常受试者更长。这些数据表明，RP闪烁ERG中的时间异常很可能是由于ERG成分的振幅和时间常数变化，而不仅仅是由于量子捕获减少或光感受器丧失。
