Sandberg M A, Sullivan P L, Berson E L
Invest Ophthalmol Vis Sci. 1981 Nov;21(5):765-9.
Cone electroretinograms were elicited with a full-field red flash after-45 min of dark adaptation from 16 patients with retinitis pigmentosa and from 17 normal subjects. The average latency and implicit time of the cone a-waves recorded from the patients were each significantly delayed (p less than 0.005) compared with the average normal values. In addition, the patient's waveforms typically showed a loss of two oscillations on the rising slope of the come b-wave. These delays and waveform changes could be simulated in normal subjects by reducing the luminance, but not the diameter, of the stimulus. These studies in normal subjects suggest that shortening of outer segments of remaining cones and not simply loss of cones account for the waveforms observed in patients with retinitis pigmentosa. The results also suggest that remaining cones generate an a-wave in the dark that is normal for a reduced cone visual pigment density.
对16例色素性视网膜炎患者和17名正常受试者进行暗适应45分钟后，用全视野红色闪光诱发锥体视网膜电图。与正常平均值相比，患者记录的锥体a波的平均潜伏期和隐含时间均显著延迟（p<0.005）。此外，患者的波形通常在锥体b波的上升斜率上显示出两个振荡的缺失。通过降低刺激的亮度而非直径，可以在正常受试者中模拟出这些延迟和波形变化。对正常受试者的这些研究表明，剩余锥体的外段缩短而非仅仅是锥体的丧失，是色素性视网膜炎患者观察到的波形的原因。结果还表明，剩余的锥体在黑暗中产生的a波对于降低的锥体视觉色素密度来说是正常的。
