Mohammadi S Saeed, Yoo Woong-Sun, Yavari Negin, Khojasteh Jafari Hassan, Or Christopher, Mobasserian Azadeh, Bazojoo Vahid, Akhavanrezayat Amir, El Feky Dalia, Elaraby Osama, Hung Jia-Horung, Yasar Cigdem, Gupta Ankur, Jain Tanya, Ganbold Battuya, Nguyen Trung Ba, Khatri Anadi, Thng Zheng Xian, Do Diana, Nguyen Quan Dong
Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA.
Department of Ophthalmology, College of Medicine, Gyeongsang National University, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea.
Life (Basel). 2025 Apr 24;15(5):694. doi: 10.3390/life15050694.
This is the studyto investigate the correlation between macular cone density (MCD) and flicker electroretinogram (ERG) response in healthy eyes. In this exploratory study, 23 eyes from 12 healthy subjects were enrolled in this study. The fixed-luminance flicker full-field electroretinogram (ffERG) responses of the retina and MCDs at 24 locations were measured using the Diopsys NOVA™ system and the rtx1 adaptive optics retinal camera, respectively. Regression analysis was employed to evaluate the correlations. The mean age of the subjects was 30 ± 3 years. The average magnitudes of the flicker response and phase response were 13.44 ± 4.88 μV and 332.63 ± 22.12°, respectively. The MCDs for all 24 locations were 15,043 ± 3511 cones/mm². Among all locations, regression analysis revealed a significant correlation only at one specific location (0, -4°) between cone density and both the mean magnitude and phase of the flicker response, with -values of 0.005 and 0.004, respectively.In conclusion, we identified a significant correlation between MCD and ffERG responses at a specific retinal locus (0, -4°). This finding may be attributed to the distribution of different cone types throughout the retina and the possibility that various cone types may contribute differently to ERG. Further studies are required to investigate this finding.
本研究旨在调查健康眼睛中黄斑区视锥细胞密度（MCD）与闪烁视网膜电图（ERG）反应之间的相关性。在这项探索性研究中，招募了12名健康受试者的23只眼睛。分别使用Diopsys NOVA™系统和rtx1自适应光学视网膜相机测量视网膜的固定亮度闪烁全视野视网膜电图（ffERG）反应以及24个位置的MCD。采用回归分析来评估相关性。受试者的平均年龄为30±3岁。闪烁反应和相位反应的平均幅度分别为13.44±4.88μV和332.63±22.12°。所有24个位置的MCD为15,043±3511个视锥细胞/mm²。在所有位置中，回归分析显示仅在一个特定位置（0，-4°）视锥细胞密度与闪烁反应的平均幅度和相位之间存在显著相关性，p值分别为0.005和0.004。总之，我们在特定视网膜位点（0，-4°）发现了MCD与ffERG反应之间的显著相关性。这一发现可能归因于不同类型视锥细胞在整个视网膜中的分布以及各种视锥细胞类型对ERG可能有不同贡献的可能性。需要进一步的研究来调查这一发现。
