Iijima H, Yamaguchi S, Hosaka O
Department of Ophthalmology, Yamanashi Medical College, Japan.
Jpn J Ophthalmol. 1993;37(2):130-5.
While the implicit time of cone responses in the electroretinogram (ERG) has been suggested to have some clinical implications in retinitis pigmentosa (RP), its evaluation is not always easy in cases of typical RP because of the small amplitudes of the responses. An intense flash stimulus would be expected to improve the recordability of photopic ERG, which represents the cone responses. However, the implicit time in normal eyes has been shown to be delayed with increased stimulus intensity. Therefore, we evaluated photopic ERGs to a white flash stimulus of 3 different intensities as well as to a red flash in 14 cases of typical RP. The recordability of the response to white flash improved with the increased intensity of the stimulus. Most RP cases showed prolonged implicit time compared with that in normal eyes to each flash stimulus. Some patients who showed exceptionally normal or mildly delayed implicit time were considered to have good prognosis since they had noticed night blindness at an older age and most of their rod response in ERG was recordable.
虽然视网膜电图（ERG）中视锥细胞反应的隐含时间已被认为在色素性视网膜炎（RP）中有一些临床意义，但在典型RP病例中，由于反应幅度小，对其进行评估并不总是容易的。强烈闪光刺激有望提高代表视锥细胞反应的明视觉ERG的可记录性。然而，正常眼睛中的隐含时间已被证明会随着刺激强度的增加而延迟。因此，我们评估了14例典型RP患者对3种不同强度的白色闪光刺激以及红色闪光的明视觉ERG。对白色闪光反应的可记录性随着刺激强度的增加而提高。与正常眼睛相比，大多数RP病例对每种闪光刺激的隐含时间都延长了。一些隐含时间异常正常或轻度延迟的患者被认为预后良好，因为他们在较年长时才注意到夜盲，并且他们ERG中的大多数视杆细胞反应是可记录的。
