Department of Ophthalmology, Medical University of Graz, Graz, Austria.
Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria ; and.
Retina. 2022 Apr 1;42(4):738-743. doi: 10.1097/IAE.0000000000003374.
Retinal vein occlusion (RVO) risk factors largely coincide with cardiovascular risk factors. Endothelin-1 (ET-1), the most potent vasoconstrictor with proinflammatory properties, is a known cardiovascular risk factor. In this study, we explore the role of serum ET-1 as a potential risk factor for RVO.
Endothelin-1 serum levels were measured in patients with RVO and control subjects. Samples were measured using the sandwich enzyme-linked immunosorbent assay for the quantitative determination of human big endothelin-1 (Biomedica Group, Austria).
The study consisted of 147 RVO patients and 150 control subjects. Median serum ET-1 was significantly higher in RVO patients (0.26 pmol/L; range, 0.19-0.37 pmol/L) compared with control subjects (0.10 pmol/L; range, 0.05-0.22 pmol/L) (P < 0.0001) independent of the occlusion site. The difference remained significant after adjusting for arterial hypertension, diabetes mellitus, history of stroke, history of myocardial infarction, history of venous thromboembolism, glomerular filtration rate, and c-reactive protein.
In conclusion, our results suggest that ET-1 is a potential risk factor for all types of RVO.
视网膜静脉阻塞 (RVO) 的风险因素在很大程度上与心血管风险因素重合。内皮素-1 (ET-1) 是一种具有促炎特性的最强血管收缩剂，是已知的心血管风险因素。在这项研究中，我们探讨了血清 ET-1 作为 RVO 潜在风险因素的作用。
使用夹心酶联免疫吸附试验定量测定人大内皮素-1（Biomedica Group，奥地利）来测量 RVO 患者和对照受试者的血清 ET-1 水平。
该研究包括 147 例 RVO 患者和 150 例对照受试者。与对照受试者（0.10 pmol/L；范围，0.05-0.22 pmol/L）相比，RVO 患者的中位血清 ET-1 水平显著更高（0.26 pmol/L；范围，0.19-0.37 pmol/L）（P<0.0001），且独立于闭塞部位。在调整了动脉高血压、糖尿病、中风史、心肌梗死史、静脉血栓栓塞史、肾小球滤过率和 C 反应蛋白后，差异仍然显著。
总之，我们的结果表明 ET-1 可能是所有类型 RVO 的潜在风险因素。
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