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The dopamine neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces histological lesions in the hypothalamus of the common marmoset.

作者信息

Gibb W R, Lees A J, Jenner P, Marsden C D

出版信息

Neurosci Lett. 1986 Mar 28;65(1):79-83. doi: 10.1016/0304-3940(86)90123-0.

DOI:10.1016/0304-3940(86)90123-0
PMID:3486388
Abstract

The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to marmosets resulted in parkinsonism and degeneration of the substantia nigra pars compacta. Examination of the hypothalamus showed neuronophagic-like rosettes of glial cells and diffuse increase in glial numbers in areas of the dopaminergic A11-A14 groups. These findings suggest that MPTP may be toxic to dopamine neurons of the hypothalamus as well as to the substantia nigra.

摘要

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